Evidence map›Paper›PMID 38819385›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Early- to mid-gestational testosterone excess leads to adverse cardiac outcomes in postpartum sheep.

Bashar Alkhatib, Joseph Ciarelli, Adel Ghnenis, Brooke Pallas, Nicholas Olivier, Vasantha Padmanabhan, Arpita Kalla Vyas

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bashar AlkhatibDepartment of Pediatrics, Washington University, St Louis, Missouri, United States.ORCID 0000-0002-3001-4337
Joseph CiarelliDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States.
Adel GhnenisDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States.
Brooke PallasUnit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, United States.
Nicholas OlivierDepartment of Veterinary Medicine, Michigan State University, Lansing, Michigan, United States.
Vasantha PadmanabhanDepartment of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0002-8443-7212
Arpita Kalla VyasDepartment of Pediatrics, Washington University, St Louis, Missouri, United States.ORCID 0000-0002-6227-7457

Funding

Gestational Hyperandrogenism in Cardiovascular ProgrammingR01HL139639 · NHLBI · WASHINGTON UNIVERSITY · PI PADMANABHAN, VASANTHA, VYAS, ARPITA · 2020 to 2023
$2.7M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL139639NHLBI NIH HHS R01 HL139639
6 · The paper itself

Abstract

Cardiovascular dysfunctions complicate 10-20% of pregnancies, increasing the risk for postpartum mortality. Various gestational insults, including preeclampsia are reported to be associated with adverse maternal cardiovascular outcomes. One such insult, gestational hyperandrogenism increases the risk for preeclampsia and other gestational morbidities but its impact on postpartum maternal health is not well known. We hypothesize that gestational hyperandrogenism such as testosterone (T) excess will adversely impact the maternal heart in the postpartum period. Pregnant ewes were injected with T propionate from

Indexed as

Postpartum PeriodAnimalsCardiac OutputCytokinesFemaleGestational AgePregnancySheepTestosteroneTestosterone PropionateVentricular Function, LeftCytokinesTestosteroneTestosterone Propionatecardiovascularhyperandrogenismmaternalovinepostpartum

Identifiers

PMID38819385
PMCPMC11687963

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.