Evidence map›Paper›PMID 38826446›Full record

ArticlebioRxiv : the preprint server for biology2024

A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by

Jianfeng Lin, Jian Miao, Katherine G Schaefer, Charles M Russell, Robert J Pyron, Fuming Zhang, Quynh T Phan, Norma V Solis-Swidergall, Hong Liu, Masato Tashiro and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Jianfeng LinInstitute for Infection and Immunity, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.ORCID 0000-0002-5202-6304
Jian MiaoPharmaceutical Sciences Program, College of Graduate Health Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Katherine G SchaeferDepartment of Physics and Astronomy, University of Missouri, Columbia, Missouri United States.
Charles M RussellDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee United States.
Robert J PyronGenome Science and Technology, University of Tennessee, Knoxville, United States.
Fuming ZhangDepartment of Chemical and Biological Engineering, and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.
Quynh T PhanInstitute for Infection and Immunity, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Norma V Solis-SwidergallInstitute for Infection and Immunity, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Hong LiuInstitute for Infection and Immunity, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Masato TashiroInstitute for Infection and Immunity, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Jonathan S DordickDepartment of Chemical and Biological Engineering, and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.
Robert J LinhardtDepartment of Chemical and Biological Engineering, and Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, USA.
Michael R YeamanInstitute for Infection and Immunity, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Gavin M KingDepartment of Physics and Astronomy, University of Missouri, Columbia, Missouri United States.
Francisco N BarreraDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee United States.
Brian M PetersDepartment of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Scott G FillerInstitute for Infection and Immunity, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.

Funding

Systems Epigenomics of Persistent Bloodstream InfectionU19AI172713 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ELAINE F REED · 2023 to 2026
$11.6M
Systems Immunolobiology of Antibiotic-Persistent MRSA InfectionU01AI124319 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI YEAMAN, MICHAEL R · 2016 to 2020
$10.1M
C. albicans invasion and proliferation during oral infectionR01DE026600 · NIDCR · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI FILLER, SCOTT G, MITCHELL, AARON P · 2017 to 2021
$3.0M
Candidalysin: a key mediator of Candida vaginitis immunopathologyR01AI134796 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Brian M Peters · 2018 to 2026
$2.9M
Mechanisms of modulation of transmembrane interactionsR35GM140846 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI BARRERA, FRANCISCO NICOLAS · 2021 to 2025
$1.9M
Glycomics-driven diagnostics for Candida aurisR21AI156573 · NIAID · RENSSELAER POLYTECHNIC INSTITUTE · PI CHATURVEDI, VISHNU, ZHANG, FUMING · 2021 to 2022
$454k
Biacore T200 Surface Plasmon Resonance SpectroscopyS10OD028523 · OD · RENSSELAER POLYTECHNIC INSTITUTE · PI LINHARDT, ROBERT J · 2020 to 2020
$344k
NIAID NIH HHS R01 AI134796NIAID NIH HHS R21 AI156573NIAID NIH HHS U01 AI124319NIAID NIH HHS U19 AI172713NIDCR NIH HHS R01 DE026600NIGMS NIH HHS R35 GM140846NIH HHS S10 OD028523
6 · The paper itself

Abstract

Candidalysin is a cytolytic peptide produced by the opportunistic fungal pathogen

Identifiers

PMID38826446
PMCPMC11142209

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.