In one paragraphArticle in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
16 authors.
Carolina G DownieDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0001-6972-9981 Heather M HighlandDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0002-3583-8239 Mona AlotaibiDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, San Diego, CA.ORCID 0000-0001-8492-9930 Barrett M WelchSchool of Public Health, University of Nevada, Reno, Reno, NV.
Annie Green HowardDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-0837-8166 Susan ChengDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0002-4977-036X Nick MillerSapient Bioanalytics, San Diego, CA.
Mohit JainSapient Bioanalytics, San Diego, CA.
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY; Public Health Sciences Division, Fred Hutchison Cancer Center, Seattle, WA.ORCID 0000-0003-1571-4615 Tao LongSapient Bioanalytics, San Diego, CA.
Tamar SoferCardioVascular Institute (CVI), Beth Israel Deaconess Medical Center, Boston, MA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.ORCID 0000-0001-8520-8860 Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Minneapolis, MN.ORCID 0000-0001-6968-6985 Bing YuDepartment of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX.ORCID 0000-0003-4818-1077 Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0002-8903-0366 Christy L AveryDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0002-1044-8162 Funding
Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3MLeveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseasesR01HL143885 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH, GORDON-LARSEN, PENNY · 2019 to 2022
$8.9MPAGE III: Population Architecture using Genomics and EpidemiologyR01HG010297 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI GIGNOUX, CHRISTOPHER R, MATISE, TARA C. · 2019 to 2022
$6.5MGene-Environment Interactions and Weight GainR01HD057194 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY, NORTH, KARI E. · 2008 to 2019
$5.9MHispanic Latino Lipid ConsortiumR01HL142302 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer Below, JOSEPH MCCORMICK · 2018 to 2026
$5.8MIntegrative Approaches to Identifying Function and Clinical Significance of Adiposity Susceptibility GenesR01DK122503 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Anne Justice, Ching-Ti Liu · 2020 to 2026
$4.5MEpidemiology of the gut microbiome, prediabetes and diabetes in LatinosR01MD011389 · NIMHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BURK, ROBERT D, KAPLAN, ROBERT C · 2016 to 2020
$4.3MFrom Biological to Social Processes: Interdisciplinary Training in Life Course ResearchT32HD091058 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT A HUMMER, Amanda L Thompson · 2017 to 2026
$4.3MThe Genetic Epidemiology of Heart, Lung, and Blood TraitsTraining Grant (GenHLB)T32HL129982 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christy Leigh Avery, KAREN L. MOHLKE · 2016 to 2026
$3.8MInflammatory mediators of cardiometabolic risk in LatinosR01HL147853 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH · 2020 to 2023
$3.8MThalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6MGENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7MNHGRI NIH HHS R01 HG010297NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL143885NHLBI NIH HHS R01 HL147853NHLBI NIH HHS R01 HL151152NHLBI NIH HHS T32 HL129982NICHD NIH HHS R01 HD057194NICHD NIH HHS T32 HD091058NIDDK NIH HHS R01 DK122503NIMHD NIH HHS R01 MD011389
6 · The paper itselfAbstract
Bioactive fatty acid-derived oxylipin molecules play key roles in mediating inflammation and oxidative stress, which underlie many chronic diseases. Circulating levels of fatty acids and oxylipins are influenced by both environmental and genetic factors; characterizing the genetic architecture of bioactive lipids could yield new insights into underlying biological pathways. Thus, we performed a genome wide association study (GWAS) of n=81 fatty acids and oxylipins in n=11,584 Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants with genetic and lipidomic data measured at study baseline (58.6% female, mean age = 46.1 years, standard deviation = 13.8 years). Additionally, given the effects of central obesity on inflammation, we examined interactions with waist circumference using two-degree-of-freedom joint tests. Heritability estimates ranged from 0% to 47.9%, and 48 of the 81oxylipins and fatty acids were significantly heritable. Moreover, 40 (49.4%) of the 81 oxylipins and fatty acids had at least one genome-wide significant (
Identifiers
PMID38826448
PMCPMC11142272
What Socratic holds
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