Evidence map›Paper›PMID 38826808›Full record

ArticleJournal of biomedical optics2024

Compact and cost-effective laser-powered speckle contrast optical spectroscopy fiber-free device for measuring cerebral blood flow.

Yu Xi Huang, Simon Mahler, Maya Dickson, Aidin Abedi, Julian Michael Tyszka, Yu Tung Lo, Jonathan Russin, Charles Liu, Changhuei Yang

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  15. Comprehensive Optimization of Interferometric Diffusing Wave Spectroscopy (iDWS).IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yu Xi HuangCalifornia Institute of Technology, Department of Electrical Engineering, Pasadena, California, United States.ORCID 0009-0000-0165-2084
Simon MahlerCalifornia Institute of Technology, Department of Electrical Engineering, Pasadena, California, United States.ORCID 0000-0002-9761-445X
Maya DicksonCalifornia Institute of Technology, Department of Electrical Engineering, Pasadena, California, United States.ORCID 0009-0000-8983-1190
Aidin AbediUniversity of Southern California, USC Neurorestoration Center, Department of Neurological Surgery, Los Angeles, California, United States.ORCID 0000-0001-8243-3878
Julian Michael TyszkaCalifornia Institute of Technology, Division of Humanities and Social Sciences, Pasadena, California, United States.ORCID 0000-0001-9342-9014
Yu Tung LoUniversity of Southern California, USC Neurorestoration Center, Department of Neurological Surgery, Los Angeles, California, United States.ORCID 0000-0002-4234-8991
Jonathan RussinUniversity of Southern California, USC Neurorestoration Center, Department of Neurological Surgery, Los Angeles, California, United States.ORCID 0000-0002-5304-4977
Charles LiuUniversity of Southern California, USC Neurorestoration Center, Department of Neurological Surgery, Los Angeles, California, United States.ORCID 0000-0001-6423-8577
Changhuei YangCalifornia Institute of Technology, Department of Electrical Engineering, Pasadena, California, United States.

Funding

Interferometric Speckle Visibility Spectroscopy for Brain Activity Associated Cerebral Blood Flow MonitoringR21EY033086 · NEI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI YANG, CHANGHUEI · 2021 to 2022
$455k
NEI NIH HHS R21 EY033086
6 · The paper itself

Abstract

Significance: In the realm of cerebrovascular monitoring, primary metrics typically include blood pressure, which influences cerebral blood flow (CBF) and is contingent upon vessel radius. Measuring CBF noninvasively poses a persistent challenge, primarily attributed to the difficulty of accessing and obtaining signal from the brain. Aim: Our study aims to introduce a compact speckle contrast optical spectroscopy device for noninvasive CBF measurements at long source-to-detector distances, offering cost-effectiveness, and scalability while tracking blood flow (BF) with remarkable sensitivity and temporal resolution. Approach: The wearable sensor module consists solely of a laser diode and a board camera. It can be easily placed on a subject's head to measure BF at a sampling rate of 80 Hz. Results: Compared to the single-fiber-based version, the proposed device achieved a signal gain of about 70 times, showed superior stability, reproducibility, and signal-to-noise ratio for measuring BF at long source-to-detector distances. The device can be distributed in multiple configurations around the head. Conclusions: Given its cost-effectiveness, scalability, and simplicity, this laser-centric tool offers significant potential in advancing noninvasive cerebral monitoring technologies.

Indexed as

Cerebrovascular CirculationEquipment DesignSpectrum AnalysisBrainCost-Benefit AnalysisHumansLasersLaser Speckle Contrast ImagingReproducibility of ResultsSignal-To-Noise RatioWearable Electronic Devicesbiomedical opticscerebral blood flowdiffuse correlation spectroscopylaser speckle imagingnoninvasive brain imagingspeckle contrast optical spectroscopy

Identifiers

PMID38826808
PMCPMC11140771

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.