Evidence map›Paper›PMID 38828998›Full record

ArticleMolecular and cellular biology2024

Reduced Protein Import via TIM23 SORT Drives Disease Pathology in TIMM50-Associated Mitochondrial Disease.

Jordan J Crameri, Catherine S Palmer, Tegan Stait, Thomas D Jackson, Matthew Lynch, Adriane Sinclair, Leah E Frajman, Alison G Compton, David Coman, David R Thorburn and 2 more

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In one paragraph

Article in Molecular and cellular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jordan J CrameriDepartment of Biochemistry and Pharmacology, The University of Melbourne, Parkville, Victoria, Australia.
Catherine S PalmerDepartment of Biochemistry and Pharmacology, The University of Melbourne, Parkville, Victoria, Australia.
Tegan StaitMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Thomas D JacksonDepartment of Biochemistry and Pharmacology, The University of Melbourne, Parkville, Victoria, Australia.
Matthew LynchNeurosciences Department, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
Adriane SinclairNeurosciences Department, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
Leah E FrajmanMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Alison G ComptonMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
David ComanDepartment of Metabolic Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
David R ThorburnMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Ann E FrazierMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Diana StojanovskiDepartment of Biochemistry and Pharmacology, The University of Melbourne, Parkville, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TIMM50 is a core subunit of the TIM23 complex, the mitochondrial inner membrane translocase responsible for the import of pre-sequence-containing precursors into the mitochondrial matrix and inner membrane. Here we describe a mitochondrial disease patient who is homozygous for a novel variant in

Indexed as

MitochondriaMitochondrial DiseasesMitochondrial Precursor Protein Import Complex ProteinsOxidative PhosphorylationProtein TransportFibroblastsHEK293 CellsHumansMembrane Transport ProteinsMitochondrial MembranesMitochondrial Membrane Transport ProteinsMitochondrial ProteinsMutationProteomicsMembrane Transport ProteinsMitochondrial Membrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsMitochondrial ProteinsTIMM50 protein, humanMitochondriamitochondrial diseasemitochondrial protein importTIM23 complexTIMM50

Identifiers

PMID38828998
PMCPMC11204040

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.