Evidence map›Paper›PMID 38829465›Full record

ArticleInternational urology and nephrology2024

The heart rate non-dipping pattern was associated with target organ damage in patients with chronic kidney disease.

Huan Zhou, Lingqiu Dong, Xiang Liu, Fangming Li, Yi Tang, Wei Qin

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In one paragraph

Article in International urology and nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Huan Zhou *Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Guoxue Alley 37, Chengdu, 610041, Sichuan, China.
Lingqiu Dong *Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Guoxue Alley 37, Chengdu, 610041, Sichuan, China.
Xiang LiuDepartment of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Fangming LiDivision of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Guoxue Alley 37, Chengdu, 610041, Sichuan, China.
Yi TangDivision of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Guoxue Alley 37, Chengdu, 610041, Sichuan, China.
Wei QinDivision of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Guoxue Alley 37, Chengdu, 610041, Sichuan, China. qinweihx@scu.edu.cn.

Funding

National Natural Science Foundation of China 81970612Sichuan Province Science and Technology Support Program 2023YFS0275, 2022YFS0150
6 · The paper itself

Abstract

purposeWe performed the study to investigate the association between heart rate (HR) non-dipping pattern and target organ damage in patients with chronic kidney disease (CKD) and hypertension.

methodsIn this cross-sectional study, 447 patients with CKD and hypertension were enrolled. 24 h ambulatory blood pressure monitoring was conducted. Linear regression and logistic regression analysis were conducted to investigate the association between HR non-dipping pattern and target organ damage, including estimated glomerular filtration rate (eGFR), left ventricular mass index (LVMI), and left ventricular hypertrophy (LVH).

resultsOverall, 261 patients (58.4%) followed non-dipping patterns of HR. HR non-dipping pattern remained to be significantly associated with reduced eGFR (β: -0.384; 95% CI: -0.719 to -0.050; p = 0.025) and the higher prevalence of CKD stages 4-5 (OR: 2.141; 95% CI: 1.153 to 3.977; p = 0.016). Meanwhile, HR non-dipping pattern was independently associated with LVMI (β: 0.021; 95% CI: 0.000 to 0.041; p = 0.049) and LVH (OR: 1.78; 95% CI: 1.07 to 2.96; p = 0.027) after adjusting for confounding factors.

conclusionsHR non-dipping pattern was independently associated with impaired renal function and cardiac damage. Non-dipping HR deserves further attention and needs to be detected and treated during the management of CKD patients.

Indexed as

Heart RateHypertensionHypertrophy, Left VentricularRenal Insufficiency, ChronicAgedCross-Sectional StudiesFemaleGlomerular Filtration RateHumansMaleMiddle AgedAmbulatory blood pressure monitoringChronic kidney diseaseHeart rate non-dippingTarget organ damage

Identifiers

PMID38829465

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.