ArticleNature genetics2024
Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets.
Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Genome-wide meta-analyses of non-response to antidepressants provide insights into underlying molecular genetics and suggest potential pharmacotherapies.Molecular psychiatry · 2026Pooled it
- Cross-ancestry analysis of gestational diabetes mellitus identifies novel loci, drug targets and biological pathways.Frontiers in endocrinology · 2026Pooled it
- Pooled it
- Rethinking schizophrenia: insights from genomics and implications for research.Molecular psychiatry · 2026Review
- Dissecting pleiotropy between major depressive disorder and physical disease comorbidities.Nature genetics · 2026Article
- Structural variants contribute substantially to complex trait heritability.Research square · 2026Article
- Genetic pleiotropy differentially linking brain variation to cannabis use and cannabis use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Genetic Correlation and Causal Inference Between Female Fat Distribution and Preeclampsia: An Integrative Genomic Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Leveraging the genetics of psychiatric disorders to prioritize potential drug targets and compounds.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Distinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlap.EBioMedicine · 2026Article
- Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations.Nature genetics · 2026Article
- Beyond Exons: Linking Noncoding Heritability and Polygenicity across Complex Human Traits and Disorders.bioRxiv : the preprint server for biology · 2026Article
- Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci.Psychiatric genetics · 2026Article
- Genetic liability to addiction underlies comorbid bipolar and substance use disorders.medRxiv : the preprint server for health sciences · 2026Article
- Genome-wide investigation highlights global and local pleiotropy linking neurodevelopmental disorders to acquired hearing problems.Psychological medicine · 2026Article
- Bivariate GSA-MiXeR: A Novel Tool for Functional Genomic Analyses Implicates Diverse Neural Cell Types for Psychiatric and Neurodegenerative Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Genome-wide association studies identify 77 loci for suicidality and provide novel biological insights.medRxiv : the preprint server for health sciences · 2025Article
- Mapping the Genetic Landscape of Psychiatric Disorders With the MiXeR Toolset.Biological psychiatry · 2025Review
- Comorbidity alters the genetic relationship between anxiety disorders and major depression.medRxiv : the preprint server for health sciences · 2025Article
- New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways.Biological psychiatry · 2025Review
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
While genome-wide association studies are increasingly successful in discovering genomic loci associated with complex human traits and disorders, the biological interpretation of these findings remains challenging. Here we developed the GSA-MiXeR analytical tool for gene set analysis (GSA), which fits a model for the heritability of individual genes, accounting for linkage disequilibrium across variants and allowing the quantification of partitioned heritability and fold enrichment for small gene sets. We validated the method using extensive simulations and sensitivity analyses. When applied to a diverse selection of complex traits and disorders, including schizophrenia, GSA-MiXeR prioritizes gene sets with greater biological specificity compared to standard GSA approaches, implicating voltage-gated calcium channel function and dopaminergic signaling for schizophrenia. Such biologically relevant gene sets, often with fewer than ten genes, are more likely to provide insights into the pathobiology of complex diseases and highlight potential drug targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.