Evidence map›Paper›PMID 38831436›Full record

ArticleDiagnostic pathology2024

Next-generation sequencing of primary testicular lymphoma and relapse in the glans penis after prophylactic radiation therapy: a rare case report.

Naoya Ishibashi, Yoko Nakanishi, Toshiya Maebayashi, Katsuhiro Miura, Sumie Ohni, Shinobu Masuda, Yasuo Amano, Masahiro Okada

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Naoya IshibashiDepartment of Radiology, Nihon University School of Medicine, 30-1, Oyaguchi Kami-cho, Itabashi, 173-8610, Tokyo, Japan. ishibashi.naoya@nihon-u.ac.jp.
Yoko NakanishiDepartment of Oncologic Pathology, Nihon University School of Medicine, Itabashi, 173-8610, Tokyo, Japan.
Toshiya MaebayashiDepartment of Radiology, Nihon University School of Medicine, 30-1, Oyaguchi Kami-cho, Itabashi, 173-8610, Tokyo, Japan.
Katsuhiro MiuraDivision of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Itabashi, 173-8610, Tokyo, Japan.
Sumie OhniDepartment of Oncologic Pathology, Nihon University School of Medicine, Itabashi, 173-8610, Tokyo, Japan.
Shinobu MasudaDepartment of Oncologic Pathology, Nihon University School of Medicine, Itabashi, 173-8610, Tokyo, Japan.
Yasuo AmanoDepartment of Radiology, Nihon University Hospital, Chiyoda, Tokyo, 101-8309, Japan.
Masahiro OkadaDepartment of Radiology, Nihon University School of Medicine, 30-1, Oyaguchi Kami-cho, Itabashi, 173-8610, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary testicular lymphoma (PTL) is relatively rare. The contralateral testis is a common site of PTL relapse; therefore, once complete remission is achieved, radiation therapy (RT) is administered to the contralateral testis to prevent relapse. CASE PRESENTATION: A 76-year-old man was diagnosed with PTL and received RT as described above. However, despite achieving and maintaining complete remission, a mass diagnosed as diffuse large B-cell lymphoma by tissue biopsy developed in the glans penis 6.5 years after prophylactic RT. We investigated whether the glans penile lymphoma was PTL relapse or a new malignancy by genomic analysis using next-generation sequencing of DNA extracted from two histopathological specimens.

conclusionsWe found the same variant allele fraction in four somatic genes (MYD88, IL7R, BLNK, and FLT3) at similar frequencies, indicating that the glans penile lymphoma had the same origin as the PTL. To the best of our knowledge, this is the first case report of PTL relapse in the glans penis.

Indexed as

High-Throughput Nucleotide SequencingLymphoma, Large B-Cell, DiffuseNeoplasm Recurrence, LocalPenile NeoplasmsTesticular NeoplasmsAgedHumansMaleCase reportGlans penisNext-generation sequencingPrimary testicular lymphomaRadiation therapy

Identifiers

PMID38831436
PMCPMC11145816

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.