Evidence map›Paper›PMID 38833523›Full record

ArticleIslets2024

Characterizing the effects of Dechlorane Plus on β-cells: a comparative study across models and species.

Kyle A van Allen, Noa Gang, Myriam P Hoyeck, Ineli Perera, Dahai Zhang, Ella Atlas, Francis C Lynn, Jennifer E Bruin

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Islets, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kyle A van AllenDepartment of Biology & Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada.
Noa GangDepartment of Biology & Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada.
Myriam P HoyeckDepartment of Biology & Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada.
Ineli PereraDepartment of Biology & Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada.
Dahai ZhangDiabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Ella AtlasEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
Francis C LynnDiabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Jennifer E BruinDepartment of Biology & Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidemiological studies consistently link environmental toxicant exposure with increased Type 2 diabetes risk. Our study investigated the diabetogenic effects of a widely used flame retardant, Dechlorane Plus (DP), on pancreatic β-cells using rodent and human model systems. We first examined pancreas tissues from male mice exposed daily to oral gavage of either vehicle (corn oil) or DP (10, 100, or 1000 μg/kg per day) and fed chow or high fat diet for 28-days

Indexed as

Hydrocarbons, ChlorinatedInsulin-Secreting CellsPolycyclic CompoundsAnimalsCells, CulturedFlame RetardantsHumansInsulinInsulin SecretionMaleMiceMice, Inbred C57BLRatsdechlorane plusFlame RetardantsHydrocarbons, ChlorinatedInsulinPolycyclic CompoundsDechlorane Plusdiabetesisletspersistent organic pollutantsstem cellsβ-cells

Identifiers

PMID38833523
PMCPMC11152096

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.