Evidence map›Paper›PMID 38833534›Full record

ReviewACS applied bio materials2024

Cracking the Code: Enhancing Molecular Tools for Progress in Nanobiotechnology.

Yelixza I Avila, Laura P Rebolledo, Elizabeth Skelly, Renata de Freitas Saito, Hui Wei, David Lilley, Robin E Stanley, Ya-Ming Hou, Haoyun Yang, Joanna Sztuba-Solinska and 11 more

Abstract readReview
In one paragraph

Review in ACS applied bio materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Yelixza I AvilaNanoscale Science Program, Department of Chemistry University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.
Laura P RebolledoNanoscale Science Program, Department of Chemistry University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.
Elizabeth SkellyNanoscale Science Program, Department of Chemistry University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.
Renata de Freitas SaitoComprehensive Center for Precision Oncology, Centro de Investigação Translacional em Oncologia (LIM24), Departamento de Radiologia e Oncologia, Faculdade de Medicina da Universidade de São Paulo and Instituto do Câncer do Estado de São Paulo, São Paulo, São Paulo 01246-903, Brazil.
Hui WeiCollege of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210023, P. R. China.ORCID 0000-0003-0870-7142
David LilleySchool of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0000-0001-6882-2818
Robin E StanleySignal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, North Carolina 27709, United States.
Ya-Ming HouThomas Jefferson University, Department of Biochemistry and Molecular Biology, 233 South 10th Street, BLSB 220 Philadelphia, Pennsylvania 19107, United States.ORCID 0000-0001-6546-2597
Haoyun YangDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
Joanna Sztuba-SolinskaVaccine Research and Development, Early Bioprocess Development, Pfizer Inc., 401 N Middletown Road, Pearl River, New York 10965, United States.
Shi-Jie ChenDepartment of Physics and Astronomy, Department of Biochemistry, Institute of Data Sciences and Informatics, University of Missouri at Columbia, Columbia, Missouri 65211, United States.ORCID 0000-0002-8093-7244
Nikolay V DokholyanDepartments of Pharmacology and Biochemistry & Molecular Biology Penn State College of Medicine; Hershey, Pennsylvania 17033, United States.ORCID 0000-0002-8225-4025
Cheemeng TanUniversity of California, Davis, California 95616, United States.
S Kevin LiDivision of Pharmaceutical Sciences, James L Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio 45267, United States.
Xiaoming HeFischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, United States.ORCID 0000-0003-0125-6086
Xiaoting ZhangDepartment of Cancer Biology, Breast Cancer Research Program, and University of Cincinnati Cancer Center, Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, United States.ORCID 0000-0002-1328-4255
Wayne MilesDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio 43210, United States.
Elisa FrancoDepartment of Mechanical and Aerospace Engineering, University of California at Los Angeles, Los Angeles, California 90024, United States.ORCID 0000-0003-1103-2668
Daniel W BinzelCenter for RNA Nanobiotechnology and Nanomedicine; College of Pharmacy, James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, United States.
Peixuan GuoCenter for RNA Nanobiotechnology and Nanomedicine; College of Pharmacy, James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, United States.ORCID 0000-0001-5706-2833
Kirill A AfoninNanoscale Science Program, Department of Chemistry University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.ORCID 0000-0002-6917-3183

Funding

Structure and Function of RNA Processing MachinesZIAES103247 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI STANLEY, ROBIN · 2015 to 2025
$22.9M
Waters Select Series Cyclic IMS for P41 Native MS Resource Application to Alzheimer's DiseaseP41GM128577 · NIGMS · OHIO STATE UNIVERSITY · PI WYSOCKI, VICKI H. · 2018 to 2022
$7.6M
tRNA in codon usageR35GM134931 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI HOU, YA-MING · 2020 to 2025
$5.4M
Nanoscale programming of cellular and physiological phenotypes: EquipmentR35GM134864 · NIGMS · UNIVERSITY OF VIRGINIA · PI Nikolay Dokholyan · 2020 to 2026
$5.2M
Role of MED1 in HER2-mediated tumorigenesisR01CA197865 · NCI · UNIVERSITY OF CINCINNATI · PI Xiaoting Zhang · 2015 to 2026
$3.7M
Structural and Functional Characterization of the SARS-CoV-2 Endoribonuclease Nsp15ZIAES103340 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI STANLEY, ROBIN · 2020 to 2025
$3.6M
New methods for computational modeling of RNA structuresR35GM134919 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI SHI-JIE CHEN · 2020 to 2026
$3.3M
Engineering and dissecting the synthetic non-dividing-but-active state of hybrid cell-materialsR35GM142788 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Cheemeng Tan · 2021 to 2026
$2.7M
Optimizing RNA nanoparticles size and shape for enhancing cancer targeting and treatmentU01CA207946 · NCI · OHIO STATE UNIVERSITY · PI CARSON, WILLIAM E., GUO, PEIXUAN · 2016 to 2020
$2.7M
Bottom-up, high-throughput prototyping of extracellular vesicle mimetics using cell-free synthetic biologyR01EB034279 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Randy Carney, Cheemeng Tan · 2023 to 2026
$2.5M
Dynamics and allostery in protein-RNA regulationR01GM120923 · NIGMS · OHIO STATE UNIVERSITY · PI MARK P. FOSTER · 2017 to 2026
$2.5M
REGULATION OF THE TRYTOPHAN GENES IN BACILLUSR01GM062750 · NIGMS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI GOLLNICK, PAUL D · 2000 to 2009
$2.1M
Intramural NIH HHS ZIA ES103247NCI NIH HHS R01 CA197865NCI NIH HHS R01 CA229869NCI NIH HHS R01 CA257961NCI NIH HHS R01 CA279810NCI NIH HHS U01 CA207946NEI NIH HHS R01 EY031452NHGRI NIH HHS R21 HG011120NIBIB NIH HHS R01 EB034279NIGMS NIH HHS P41 GM128577NIGMS NIH HHS R01 GM062750NIGMS NIH HHS R01 GM077234NIGMS NIH HHS R01 GM120923NIGMS NIH HHS R01 GM141394NIGMS NIH HHS R35 GM134864NIGMS NIH HHS R35 GM134919NIGMS NIH HHS R35 GM134931NIGMS NIH HHS R35 GM139587NIGMS NIH HHS R35 GM142788
6 · The paper itself

Abstract

Nature continually refines its processes for optimal efficiency, especially within biological systems. This article explores the collaborative efforts of researchers worldwide, aiming to mimic nature's efficiency by developing smarter and more effective nanoscale technologies and biomaterials. Recent advancements highlight progress and prospects in leveraging engineered nucleic acids and proteins for specific tasks, drawing inspiration from natural functions. The focus is developing improved methods for characterizing, understanding, and reprogramming these materials to perform user-defined functions, including personalized therapeutics, targeted drug delivery approaches, engineered scaffolds, and reconfigurable nanodevices. Contributions from academia, government agencies, biotech, and medical settings offer diverse perspectives, promising a comprehensive approach to broad nanobiotechnology objectives. Encompassing topics from mRNA vaccine design to programmable protein-based nanocomputing agents, this work provides insightful perspectives on the trajectory of nanobiotechnology toward a future of enhanced biomimicry and technological innovation.

Indexed as

Biocompatible MaterialsNanotechnologyBiotechnologyDrug Delivery SystemsHumansBiocompatible MaterialsISRNNmRNA vaccinesnanobiotechnologynanoparticlesnucleic acid therapiesRNA nanotechnology

Identifiers

PMID38833534
PMCPMC11190997

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.