Evidence map›Paper›PMID 38835246›Full record

ArticleJournal of the Royal Society, Interface2024

Digital twinning of cardiac electrophysiology for congenital heart disease.

Matteo Salvador, Fanwei Kong, Mathias Peirlinck, David W Parker, Henry Chubb, Anne M Dubin, Alison L Marsden

Abstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Potential of Digital Twins for Pediatric Rare Diseases.CPT: pharmacometrics & systems pharmacology · 2026
    Review
  6. Review
  7. Full-field surrogate modeling of cardiac electrophysiology encoding geometric variability.Computer methods in applied mechanics and engineering · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Matteo SalvadorInstitute for Computational and Mathematical Engineering, Stanford University , Stanford, CA, USA.ORCID 0000-0002-4937-5538
Fanwei KongInstitute for Computational and Mathematical Engineering, Stanford University , Stanford, CA, USA.
Mathias PeirlinckDepartment of Biomechanical Engineering, Delft University of Technology , Delft, The Netherlands.
David W ParkerStanford Research Computing Center, Stanford University , Stanford, CA, USA.
Henry ChubbPediatric Cardiology, Stanford University , Stanford, CA, USA.
Anne M DubinPediatric Cardiology, Stanford University , Stanford, CA, USA.
Alison L MarsdenInstitute for Computational and Mathematical Engineering, Stanford University , Stanford, CA, USA.

Funding

A multi-physics simulator for pediatric cardiac surgical planningR01HL173845 · NHLBI · STANFORD UNIVERSITY · PI Daniel B Ennis, MICHAEL MA · 2024 to 2026
$2.3M
NHLBI NIH HHS R01 HL173845
6 · The paper itself

Abstract

In recent years, blending mechanistic knowledge with machine learning has had a major impact in digital healthcare. In this work, we introduce a computational pipeline to build certified digital replicas of cardiac electrophysiology in paediatric patients with congenital heart disease. We construct the patient-specific geometry by means of semi-automatic segmentation and meshing tools. We generate a dataset of electrophysiology simulations covering cell-to-organ level model parameters and using rigorous mathematical models based on differential equations. We previously proposed Branched Latent Neural Maps (BLNMs) as an accurate and efficient means to recapitulate complex physical processes in a neural network. Here, we employ BLNMs to encode the parametrized temporal dynamics of

Indexed as

ElectrocardiographyHeart Defects, CongenitalModels, CardiovascularChildHumansneural mapsnumerical simulationsparameter estimationsingle ventricle physiologyuncertainty quantification

Identifiers

PMID38835246
PMCPMC11285762

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.