Evidence map›Paper›PMID 38835249›Full record

ArticleJournal of applied gerontology : the official journal of the Southern Gerontological Society2024

Exercise: Just What the Doctor Ordered, But Why? Elucidating Mechanisms for Women's Increased High-Density Lipoprotein Benefit From Exercise and for the Health ABC Study.

Rachel A Bernier, Erin E Sundermann, Steven D Edland, Kacie D Deters, Alyx L Shepherd, Alexandra L Clark, Eric J Shiroma, Sarah J Banks

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied gerontology : the official journal of the Southern Gerontological Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rachel A BernierUniversity of California, San Diego, San Diego, CA, USA.
Erin E SundermannUniversity of California, San Diego, San Diego, CA, USA.
Steven D EdlandUniversity of California, San Diego, San Diego, CA, USA.
Kacie D DetersUniversity of California Los Angeles, Los Angeles, CA, USA.
Alyx L ShepherdUniversity of California, San Diego, San Diego, CA, USA.
Alexandra L ClarkVA San Diego Healthcare System, La Jolla, CA, USA.
Eric J ShiromaNational Institute on Aging, National Institutes of Health, Washington, DC, USA.
Sarah J BanksUniversity of California, San Diego, San Diego, CA, USA.ORCID 0009-0001-6156-0605

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9M
Sex-specific cognitive expression and risk in preclinical Alzheimer's diseaseR01AG066088 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANKS, SARAH · 2019 to 2023
$3.9M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
NIA NIH HHS N01-AG-6-2101NIA NIH HHS N01-AG-6-2103NIA NIH HHS N01-AG-6-2106NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG028050NIA NIH HHS R01 AG066088NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

High-density lipoprotein (HDL) is protective against cardiovascular disease. Exercise can increase HDL concentration, and some evidence suggests that this effect occurs more strongly in women than in men. Both HDL and exercise are associated with inflammation. We hypothesized a sex-by-exercise interaction on HDL level, whereby women would benefit from exercise more strongly than men, and tumor necrosis factor alpha and serum soluble tumor necrosis factor receptor-2 would mediate this relationship. This study included 2,957 older adult participants (1,520 women; 41% Black, 59% White; 73.6-years-old) from the Health, Aging, and Body Composition study. Regression models revealed a positive exercise-HDL relationship in women only (sex-by-exercise interaction: β = 0.09,

Indexed as

ExerciseLipoproteins, HDLTumor Necrosis Factor-alphaAgedAgingCardiovascular DiseasesFemaleHumansInflammationMaleReceptors, Tumor Necrosis Factor, Type IISex FactorsLipoproteins, HDLReceptors, Tumor Necrosis Factor, Type IITumor Necrosis Factor-alphaagingcognitionexercisehigh-density lipoproteininflammationtumor necrosis factorwomen

Identifiers

PMID38835249
PMCPMC12984035

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.