ArticleFrontiers in immunology2024
Dietary 5-hydroxytryptophan improves sheep growth performance by enhancing ruminal functions, antioxidant capacity, and tryptophan metabolism:
Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Recent advances in nonprotein amino acids: insights from function to biosynthesis.Journal of animal science and biotechnology · 2026Review
- Rapid LC-MS/MS-based quantitative serum tryptophan metabolomics platform identifies and monitors novel biomarkers for diabetic kidney disease.Analytical and bioanalytical chemistry · 2026Article
- Metabolic and metataxonomic changes in lactating holstein dairy cows during the transition from heat stress to the recovery period.Journal of animal science and technology · 2026Article
- Effects of Rumen-Protected 5-Hydroxytryptophan and Melatonin Supplementation on Antioxidant Capacity, Meat Quality, and Shelf Life of Hu Sheep.Animals : an open access journal from MDPI · 2025Article
- Article
- Comparative analysis of cecal microbiota and metabolites in relation to growth performance of Tibetan and Hu sheep.Frontiers in microbiology · 2025Article
- Effects of compound yeast culture on growth performance, antioxidant function and inflammatory factors of Hu sheep.Frontiers in veterinary science · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
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Abstract
Background: Hydroxytryptophan (5-HTP) can regulate the synthesis of 5-Hydroxytryptamine (5-HT) and melatonin (MT). In a previous metabolome analysis, we found that 5-HTP is an effective ingredient in yeast culture for regulating rumen fermentation. However, research on the effect of this microbial product (5-HTP) as a functional feed additive in sheep production is still not well explained. Therefore, this study examined the effects of 5-HTP on sheep rumen function and growth performance using Methods: A two-factor in vitro experiment involving different 5-HTP doses and fermentation times was conducted. Then, in the Results: The results showed that 5-HTP supplementation had a significant effect on Conclusion: Dietary 5-HTP (8 mg/kg DM) improves sheep growth performance by enhancing ruminal functions, antioxidant capacity, and tryptophan metabolism. This study can provide a foundation for the development of 5-HTP as a functional feed additive in ruminants' production.
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Registered trials
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