ReviewJournal of stroke2024
Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities.
Review in Journal of stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Diabetic cerebral microvascular disorder: from key pathologies to targeted interventions.Annals of medicine · 2026Review
- Congenital internal carotid artery hypoplasia in a symptomatic young adult: A case report.Radiology case reports · 2026Article
- Association between cardiovascular disease risk factors and white matter lesions: The Tohoku Medical Megabank Cohort Study.Journal of atherosclerosis and thrombosis · 2026Article
- Multiomics Profiling Supports Cathepsin B as a Protective Factor in Cerebral Small Vessel Disease.Research square · 2026Article
- The Role of Leukoaraiosis and Microbleeds in Acute Ischemic Stroke Outcome Prediction.Journal of clinical medicine · 2026Article
- Multimodal Magnetic Resonance Imaging Signatures of White Matter Hyperintensities: Mechanistic Insights Into Pathobiological Heterogeneity.Journal of stroke · 2026Review
- The mediating role of white matter hyperintensity in the association between malnutrition and cognitive impairment in patients with cerebral small vessel disease.Frontiers in neurology · 2026Article
- Analysis of Risk Factors for Leukoaraiosis: A Multicenter Retrospective Study.Brain and behavior · 2025Article
- Neuroprotective Effect of Rosuvastatin Calcium Combined with Hyperbaric Oxygen Mediated p38MAPK Pathway in Rats with Leukoaraiosis.Cell biochemistry and biophysics · 2025Article
- Glymphopathy and Reduced Processing Speed in Community-Dwelling Adults with Silent Cerebral Small Vessel Disease: A DTI-ALPS Study.Journal of clinical medicine · 2025Article
- White matter hyperintensity burden in young patent foramen ovale patients and its correlation with migraine.Frontiers in neurology · 2025Article
- White matter hyperintensity burden and infarct volume predict functional outcomes in anterior choroidal artery stroke: a multimodal MRI study.Frontiers in neuroscience · 2025Article
- Association between cerebral small vessel disease and malnutrition risk: a retrospective cross-sectional study.Frontiers in neurology · 2025Article
- Deep and periventricular white matter hyperintensities exhibit differential metabolic profiles in arteriosclerotic cerebral small vessel disease: an untargeted metabolomics study.Frontiers in neuroscience · 2025Article
- Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysis.Frontiers in neurology · 2025Review
- Exploration of heterogeneity in risk factors associated with imaging subtypes of white matter hyperintensities on fluid-attenuated inversion recovery magnetic resonance imaging.Frontiers in neurology · 2025Article
- Association of white matter hyperintensity burden and infarct volume in the anterior choroidal artery territory with early neurological progression: a dual-center retrospective study.Frontiers in aging neuroscience · 2025Article
- Uncovering the new landscape of leukoaraiosis through the circular RNA-miRNA-mRNA axis.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Leukoaraiosis (LA) manifests as cerebral white matter hyperintensities on T2-weighted magnetic resonance imaging scans and corresponds to white matter lesions or abnormalities in brain tissue. Clinically, it is generally detected in the early 40s and is highly prevalent globally in individuals aged >60 years. From the imaging perspective, LA can present as several heterogeneous forms, including punctate and patchy lesions in deep or subcortical white matter; lesions with periventricular caps, a pencil-thin lining, and smooth halo; as well as irregular lesions, which are not always benign. Given its potential of having deleterious effects on normal brain function and the resulting increase in public health burden, considerable effort has been focused on investigating the associations between various risk factors and LA risk, and developing its associated clinical interventions. However, study results have been inconsistent, most likely due to potential differences in study designs, neuroimaging methods, and sample sizes as well as the inherent neuroimaging heterogeneity and multi-factorial nature of LA. In this article, we provided an overview of LA and summarized the current knowledge regarding its epidemiology, neuroimaging classification, pathological characteristics, risk factors, and potential intervention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.