Evidence map›Paper›PMID 38836646›Full record

ReviewHepatology (Baltimore, Md.)2026

Physical exercise in liver diseases.

Yunwei Zhang, Chunyan Cao, Chaofan Li, Russell G Witt, Hai Huang, Allan Tsung, Hongji Zhang

Abstract readReview
In one paragraph

Review in Hepatology (Baltimore, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yunwei ZhangDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-7609-8492
Chunyan CaoDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-7698-1381
Chaofan LiDepartment of Medicine, Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-5426-1498
Russell G WittDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0003-3747-8633
Hai HuangDivision of Hepatology, Center for Immunology and Inflammation, Departments of Molecular Medicine, Medicine, and Surgery at the School of Medicine, Feinstein Institutes for Medical Research, Manhasset, New York, USA.ORCID 0000-0001-7430-0119
Allan TsungDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-3916-8965
Hongji ZhangDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-7704-4365

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael D. Solga · 1987 to 2026
$72.1M
Surgery triggered immune response and liver metastasesR01CA214865 · NCI · UNIVERSITY OF VIRGINIA · PI Allan Tsung · 2018 to 2026
$3.4M
Endogenous regulators of inflammation in liver ischemia/reperfusionR01GM095566 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TSUNG, ALLAN · 2011 to 2019
$2.7M
Preoperative exercise therapy triggers trained immunity in KCs via cholinergic anti-inflammatory pathwayR01GM137203 · NIGMS · OHIO STATE UNIVERSITY · PI HUANG, HAI · 2020 to 2025
$2.0M
NCI NIH HHS P30 CA044579NCI NIH HHS R01 CA214865NIGMS NIH HHS R01 GM095566NIGMS NIH HHS R01 GM137203
6 · The paper itself

Abstract

Liver diseases contribute to ~2 million deaths each year and account for 4% of all deaths globally. Despite various treatment options, the management of liver diseases remains challenging. Physical exercise is a promising nonpharmacological approach to maintain and restore homeostasis and effectively prevent and mitigate liver diseases. In this review, we delve into the mechanisms of physical exercise in preventing and treating liver diseases, highlighting its effects on improving insulin sensitivity, regulating lipid homeostasis, and modulating immune function. In addition, we evaluate the impact of physical exercise on various liver diseases, including liver ischemia/reperfusion injury, cardiogenic liver disease, metabolic dysfunction-associated steatotic liver disease, portal hypertension, cirrhosis, and liver cancer. In conclusion, the review underscores the effectiveness of physical exercise as a beneficial intervention in combating liver diseases.

Indexed as

ExerciseExercise TherapyLiver DiseasesHumansInsulin Resistance

Identifiers

PMID38836646
PMCPMC11702854

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.