Evidence map›Paper›PMID 38837110›Full record

ArticleDigestive diseases and sciences2024

Role of Environmental Risk Factors in the Etiology of Inflammatory Bowel Diseases: A Multicenter Study.

Cemile Cansu Alperen, Barıs Soydas, Ender Serin, Mustafa Erbayrak, Nurten Akyurek Savas, Gulhan Kanat Unler, Cenk Emre Meral, Ugur Toprak, Ahmet Sedat Boyacioglu, Ulku Dagli

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Key Interleukins in Inflammatory Bowel Disease-A Review of Recent Studies.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cemile Cansu AlperenDepartment of Internal Medicine, Faculty of Medicine, Baskent University, Ankara, Turkey. cansu.baygin@hotmail.com.ORCID http://orcid.org/0000-0001-9227-0953
Barıs SoydasDepartment of Gastroenterology, Baskent University Adana Medical and Research Center, Adana, Turkey.
Ender SerinDepartment of Gastroenterology, Baskent University Adana Medical and Research Center, Adana, Turkey.
Mustafa ErbayrakDepartment of Gastroenterology, Baskent University Alanya Medical and Research Center, Alanya, Turkey.
Nurten Akyurek SavasDepartment of Gastroenterology, Baskent University Istanbul Hospital, Istanbul, Turkey.
Gulhan Kanat UnlerDepartment of Gastroenterology, Baskent University Konya Medical and Research Center, Konya, Turkey.
Cenk Emre MeralDepartment of Gastroenterology, Baskent University Izmir Medical and Research Center, Izmir, Turkey.
Ugur ToprakDepartment of Biostatistics, Faculty of Medicine, Baskent University, Ankara, Turkey.
Ahmet Sedat BoyaciogluDepartment of Gastroenterology, Faculty of Medicine, Baskent University, Ankara, Turkey.
Ulku DagliDepartment of Gastroenterology, Faculty of Medicine, Baskent University, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe increasing global incidence and prevalence of inflammatory bowel disease (IBD) necessitates an investigation into the potential influence of environmental risk factors on its origin.

aimThis multicenter case-control study aimed to investigate potential environmental risk factors contributing to IBD development in Turkey.

methodsThe study included 156 Crohn's disease (CD), 277 ulcerative colitis (UC) patients, and 468 controls (matched for age and gender) from six hospitals' gastroenterology departments. Data collection relied on the International Organization of IBD's questionnaire on environmental factors. Each environmental factor was initially analyzed using univariate and subsequently multivariate logistic regression models.

resultsIn the multivariate model, regular coffee consumption was associated with decreased odds for both CD (OR 0.28; 95% CI 0.14-0.55) and UC (OR 0.25; 95% CI 0.15-0.42). Stress was associated with UC (OR 3.27; 95% CI 1.76-6.10) and CD (OR 4.40; 95% CI 2.12-9.10) development. A history of childhood infectious diseases (gastroenteritis, upper respiratory tract infections, etc.) raised the odds for both CD (OR 9.45; 95% CI 2.51-35.6) and UC (OR 7.56; 95% CI 1.57-36.4). Conversely, consuming well/spring water (OR 0.22; 95% CI 0.10-0.50) and childhood antibiotic use (OR 0.41; 95% CI 0.18-0.93) showed a positive association against UC. Increased consumption of refined sugar and industrial food products emerged as risk factors for IBD. Smoking increased the risk for CD (OR 2.38; 95% CI 1.16-4.91), while ex-smoking increased the risk for UC (OR 3.16; 95% CI 1.19-8.37).

conclusionsThis study represents the first multicenter case-control study in Turkey examining the effects of environmental factors on IBD. It revealed that coffee consumption is positively associated, while stress and childhood infection-related diseases are risk factors. These findings, which are not supported by other studies, provide insight into the relationships between these factors and IBD.

Indexed as

CoffeeColitis, UlcerativeCrohn DiseaseAdolescentAdultCase-Control StudiesEnvironmental ExposureFemaleHumansMaleMiddle AgedRisk FactorsStress, PsychologicalTurkeyYoung AdultCoffeeCrohn’s diseaseEpidemiologyEtiologyInflammatory bowel diseaseUlcerative colitis

Identifiers

PMID38837110

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.