ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2024
Effects of age on microvascular function in patients with normal coronary arteries.
Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Comparative assessment of non-invasive imaging methods for coronary artery disease: coronary computed tomography angiography, computed tomography-derived fractional flow reserve and instantaneous wave-free ratio computed tomography.The international journal of cardiovascular imaging · 2026Review
- Leg muscle microvascular function is associated with dynamic but not static balance performance in older adults.BMC geriatrics · 2026Article
- Impact of Age and Sex on Coronary Flow Reserve and Microvascular Function in Patients With Angina and Nonobstructive Coronary Arteries.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Routine diagnosis of ANOCA/INOCA: pros and cons.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
- The role of coronary microcirculation in heart failure with preserved ejection fraction: An unceasing odyssey.Heart failure reviews · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been suggested that coronary microvascular function decreases with age, irrespective of the presence of epicardial atherosclerosis.
aimsOur aim is to quantitatively investigate the effects of age on microvascular function in patients with normal coronary arteries.
methodsIn 314 patients with angina with no obstructive coronary artery disease (ANOCA), microcirculatory function was tested using the continuous thermodilution method. In 305 patients, the association between age and both resting and hyperaemic myocardial blood flow (Q), microvascular resistance (R
resultsThe mean age was 59±9 years with a range from 22 to 79 years. The mean resting Q (Q
conclusionsThere is an age-dependent physiological increase in minimal microvascular resistance and decrease in microvascular function, which is represented by a decreased MRR and is independent of atherosclerosis. The age-dependent decrease in MRR was present in both patients with and without CMD and was most evident in patients with smooth coronary arteries.
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