Evidence map›Paper›PMID 38843407›Full record

ArticleThe Journal of physiology2024

α-Adrenergic regulation of skeletal muscle blood flow during exercise in patients with heart failure with preserved ejection fraction.

Jeremy K Alpenglow, Kanokwan Bunsawat, Michael A Francisco, Ryan M Broxterman, Jesse C Craig, Jarred J Iacovelli, Joshua C Weavil, Jonathan D Harrison, David E Morgan, Natalie A Silverton and 4 more

Abstract read
In one paragraph

Article in The Journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Maintained sympathetic reactivity but blunted pressor response to static handgrip exercise in heart failure with preserved ejection fraction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jeremy K AlpenglowDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0001-9769-4966
Kanokwan BunsawatDepartment of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, USA.
Michael A FranciscoGeriatric Research, Education, and Clinical Center, VAMC, Salt Lake City, UT, USA.
Ryan M BroxtermanDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-7388-2214
Jesse C CraigDepartment of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0001-5959-4139
Jarred J IacovelliDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
Joshua C WeavilGeriatric Research, Education, and Clinical Center, VAMC, Salt Lake City, UT, USA.ORCID 0000-0002-2032-8498
Jonathan D HarrisonDepartment of Internal Medicine, Division of Cardiovascular Medicine, Salt Lake City, UT, USA.
David E MorganDepartment of Anesthesiology, University of Utah, Salt Lake City, UT, USA.
Natalie A SilvertonGeriatric Research, Education, and Clinical Center, VAMC, Salt Lake City, UT, USA.
Van R ReeseDepartment of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-8780-4276
Christy L MaDepartment of Internal Medicine, Division of Cardiovascular Medicine, Salt Lake City, UT, USA.
John J RyanDepartment of Internal Medicine, Division of Cardiovascular Medicine, Salt Lake City, UT, USA.
D Walter WrayDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-6907-1734

Funding

Autonomic Dysfunction in Patients with HFpEFR01HL162856 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2023 to 2026
$2.7M
Cardiovascular and neuromuscular issues in chronic painR01HL170007 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MARKUS AMANN, D. Walter Wray · 2024 to 2026
$2.3M
Cardiovasomobility Research Training ProgramT32HL139451 · NHLBI · UNIVERSITY OF UTAH · PI SUPIANO, MARK A, WRAY, D. WALTER · 2018 to 2022
$1.4M
Novel Approaches for Improving Vascular Function in Veterans with HFpEFI01CX002152 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI D. Walter Wray · 2021 to 2026
–
Improving exercise rehabilitation efficacy and outcomes in Veterans with peripheral artery disease: Targeting oxidative stress and inflammationIK2RX003913 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI CRAIG, JESSE CHARLES · 2023 to 2025
–
Efficacy of exercise training in patients with HFpEFI01RX003343 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI MARKUS AMANN · 2021 to 2026
–
Mechanisms of Impaired Skeletal Muscle Blood Flow and Exercise Intolerance in Veterans with Heart Failure with Preserved Ejection Fraction: Efficacy of Knee Extensor TrainingIK2RX003670 · VA · VA SALT LAKE CITY HEALTHCARE SYSTEM · PI Kanokwan Bunsawat · 2022 to 2026
–
American Heart Association (AHA) I8POST33960192American Heart Association-American Stroke Association AHA_18POST33960169CSRD VA I01 CX002152CSRD VA IK1 CX002567HHS | National Institutes of Health (NIH) HL139451HHS | National Institutes of Health (NIH) HL162856NHLBI NIH HHS R01 HL162856NHLBI NIH HHS R01 HL170007NHLBI NIH HHS T32 HL139451RRD VA I01 RX003343RRD VA IK2 RX003670RRD VA IK2 RX003913US Department of Veterans Affairs (VA) CX002152US Department of Veterans Affairs (VA) IK2RX003670US Department of Veterans Affairs (VA) IK2RX003913
6 · The paper itself

Abstract

Heart failure with preserved ejection fraction (HFpEF) has been characterized by lower blood flow to exercising limbs and lower peak oxygen utilization (

Indexed as

ExerciseHeart FailureMuscle, SkeletalStroke VolumeAdrenergic alpha-AntagonistsAgedFemaleHumansLegMaleMiddle AgedOxygen ConsumptionPhentolaminePhenylephrineRegional Blood FlowAdrenergic alpha-AntagonistsPhentolaminePhenylephrineblood flowexerciseheart failureα‐adrenergic signaling

Identifiers

PMID38843407
PMCPMC11250769

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.