Evidence map›Paper›PMID 38843983›Full record

ArticleExperimental eye research2024

Effect of hydrogen peroxide on lens transparency, intracellular pH, gap junction coupling, hydrostatic pressure and membrane water permeability.

Kulandaiappan Varadaraj, Junyuan Gao, Richard T Mathias, Sindhu Kumari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. CatExperimental eye research · 2026
    Article
  2. Functional characterization of CatExperimental eye research · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kulandaiappan VaradarajPhysiology and Biophysics, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA. Electronic address: kulandaiappan.varadaraj@stonybrook.edu.
Junyuan GaoPhysiology and Biophysics, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Richard T MathiasPhysiology and Biophysics, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Sindhu KumariPhysiology and Biophysics, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.

Funding

Roles of Lens Aquaporins and GPX1 in Hydrogen Peroxide Balance, Homeostasis, and AgingR01EY033346 · NEI · STATE UNIVERSITY NEW YORK STONY BROOK · PI Kulandaiappan Varadaraj · 2022 to 2026
$1.9M
Role of aquaporins in mammalian lens development,transparency and homeostasisR01EY026155 · NEI · STATE UNIVERSITY NEW YORK STONY BROOK · PI VARADARAJ, KULANDAIAPPAN · 2016 to 2019
$1.6M
NEI NIH HHS R01 EY026155NEI NIH HHS R01 EY033346
6 · The paper itself

Abstract

Clouding of the eye lens or cataract is an age-related anomaly that affects middle-aged humans. Exploration of the etiology points to a great extent to oxidative stress due to different forms of reactive oxygen species/metabolites such as Hydrogen peroxide (H

Indexed as

Cell Membrane PermeabilityGap JunctionsHydrogen PeroxideHydrostatic PressureLens, CrystallineMice, Inbred C57BLAnimalsCataractHydrogen-Ion ConcentrationMiceOxidantsOxidative StressHydrogen PeroxideOxidantsAquaporinConnexinGap junction couplingHydrogen peroxideHydrostatic pressureIntracellular pHLensMembrane water permeability

Identifiers

PMID38843983
PMCPMC11302404

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.