Evidence mapPaperPMID 38844121Full record

ReviewJournal of advanced research2025

Egypt Genome: Towards an African new genomic era.

Khaled Amer, Neveen A Soliman, Sameh Soror, Yehia Z Gad, Ahmed Moustafa, Mohamed A Elmonem, May Amer, Ameera Ragheb, Amira Kotb, Tarek Taha and 4 more

Abstract readReview
In one paragraph

Review in Journal of advanced research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Association ofBiomedicines · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Khaled AmerEgypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt. Electronic address: khaled.amer@ecrrm.ac.eg.
Neveen A SolimanEgypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt; Department of Pediatrics, Center of Pediatric Nephrology and Transplantation, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: nsoliman@kasralainy.edu.eg.
Sameh SororDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Yehia Z GadDepartment of Medical Molecular Genetics, Human Genetics and Genome Research Institute, National Research Center, Cairo, Egypt; Ancient DNA Laboratory, National Museum of Egyptian Civilization, Egypt.
Ahmed MoustafaDepartment of Biology, and Bioinformatics and Integrative Genomics Lab, American University in Cairo, Cairo, Egypt.
Mohamed A ElmonemEgypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt; Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
May AmerEgypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt.
Ameera RaghebEgypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt.
Amira KotbEgypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt; Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Tarek TahaEgypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt.
Wael AliEgypt Center for Research and Regenerative Medicine (ECRRM), Cairo, Egypt.
Mahmoud SakrAcademy of Scientific Research & Technology, Egypt.
Khaled Abdel GhaffarDepartment of Oral Medicine, Periodontolgy and Diagnosis, Faculty of Dentistry, Ain Shams University, Cairo, Egypt; Ministry of Health and Population, Cairo, Egypt.
Scientific Committee Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudying the human genome is crucial to embrace precision medicine through tailoring treatment and prevention strategies to the unique genetic makeup and molecular information of individuals. After human genome project (1990-2003) generated the first full sequence of a human genome, there have been concerns towards Northern bias due to underrepresentation of other populations. Multiple countries have now established national genome projects aiming at the genomic knowledge that can be harnessed from their populations, which in turn can serve as a basis for their health care policies in the near future. AIM OF REVIEW: The intention is to introduce the recently established Egypt Genome (EG) to delineate the genomics and genetics of both the modern and Ancient Egyptian populations. Leveraging genomic medicine to improve precision medicine strategies while building a solid foundation for large-scale genomic research capacity is the fundamental focus of EG. KEY SCIENTIFIC CONCEPTS: EG generated genomic knowledge is predicted to enrich the existing human genome and to expand its diversity by studying the underrepresented African/Middle Eastern populations. The insightful impact of EG goes beyond Egypt and Africa as it fills the knowledge gaps in health and disease genomics towards improved and sustainable genomic-driven healthcare systems for better outcomes. Promoting the integration of genomics into clinical practice and spearheading the implementation of genomic-driven healthcare and precision medicine is therefore a key focus of EG. Mining into the wealth of Ancient Egyptian Genomics to delineate the genetic bridge between the contemporary and Ancient Egyptian populations is another excitingly unique area of EG to realize the global vision of human genome.

Indexed as

Genome, HumanGenomicsEgyptEgypt, AncientHuman Genome ProjectHumansPrecision MedicineAncient EgyptiansGenomic medicineMonogenic diseasesPopulation genomePrecision medicineWhole genome sequencing

Identifiers

PMID38844121
PMCPMC12126713

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.