Evidence map›Paper›PMID 38844783›Full record

ArticleNature communications2024

KSHV infection of B cells primes protective T cell responses in humanized mice.

Nicole Caduff, Lisa Rieble, Michelle Böni, Donal McHugh, Romin Roshan, Wendell Miley, Nazzarena Labo, Sumanta Barman, Matthew Trivett, Douwe M T Bosma and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Single-cell and spatial transcriptomics reveal mTOR-driven cellular fate of spindle cells and immune evasion in classic Kaposi's sarcoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. Article
  3. Review
  4. LANA-specific CD4Nature communications · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. HHV-8/KSHV in Solid Organ Transplantation: Current Gaps of Knowledge and Future Directions.Transplant infectious disease : an official journal of the Transplantation Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nicole Caduff *Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Lisa Rieble *Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0001-9773-8607
Michelle BöniViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Donal McHughViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-3791-0038
Romin RoshanViral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0003-3449-3141
Wendell MileyViral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Nazzarena LaboViral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Sumanta BarmanDepartment of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-4485-402X
Matthew TrivettViral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Douwe M T BosmaViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-3500-8649
Julia RühlViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Norbert GoebelsDepartment of Neurology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Denise WhitbyViral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0002-7407-2563
Christian MünzViral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland. christian.muenz@uzh.ch.ORCID http://orcid.org/0000-0001-6419-1940

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
NCI NIH HHS 75N91019D00024
6 · The paper itself

Abstract

Kaposi sarcoma associated herpesvirus (KSHV) is associated with around 1% of all human tumors, including the B cell malignancy primary effusion lymphoma (PEL), in which co-infection with the Epstein Barr virus (EBV) can almost always be found in malignant cells. Here, we demonstrate that KSHV/EBV co-infection of mice with reconstituted human immune systems (humanized mice) leads to IgM responses against both latent and lytic KSHV antigens, and expansion of central and effector memory CD4

Indexed as

B-LymphocytesCD8-Positive T-LymphocytesHerpesvirus 8, HumanAnimalsAntibodies, ViralAntigens, ViralCD4-Positive T-LymphocytesCoinfectionEpstein-Barr Virus InfectionsHerpesviridae InfectionsHerpesvirus 4, HumanHumansImmunoglobulin MLymphoma, Primary EffusionMiceMice, SCIDAntibodies, ViralAntigens, ViralImmunoglobulin M

Identifiers

PMID38844783
PMCPMC11156630

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.