Evidence mapPaperPMID 38847653Full record

ReviewTechnology in cancer research & treatment

DHCR24 in Tumor Diagnosis and Treatment: A Comprehensive Review.

Xin Fu, Zhaosong Wang

Abstract readReview
In one paragraph

Review in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xin FuDepartment of Gynecologic Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Zhaosong WangNational Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.ORCID 0000-0003-2217-5138

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As an important nutrient in the human body, cholesterol can not only provide structural components for the body's cells, but also can be transformed into a variety of active substances to regulate cell signaling pathways. As an important cholesterol synthase, DHCR24 participates in important regulatory processes in the body. The application of DHCR24 in tumor clinical diagnosis and treatment also attracts much attention. This article reviews the structure and regulatory characteristics of DHCR24, and the research of DHCR24 on tumor progression. We summarize the possible mechanisms of DHCR24 promoting tumor progression through reactive oxygen species (ROS), p53, Ras and PI3K-AKT pathways. Through our review, we hope to provide more research ideas and reference value for the application of DHCR24 in tumor prevention and treatment.

Indexed as

NeoplasmsSignal TransductionAnimalsBiomarkers, TumorDisease ManagementHumansOxidoreductases Acting on CH-CH Group DonorsPhosphatidylinositol 3-KinasesReactive Oxygen SpeciesBiomarkers, TumorOxidoreductases Acting on CH-CH Group DonorsPhosphatidylinositol 3-KinasesReactive Oxygen SpeciesapoptosischolesterolDHCR24ROStumor

Identifiers

PMID38847653
PMCPMC11162140

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.