Evidence map›Paper›PMID 38848188›Full record

ArticleJournal of Alzheimer's disease : JAD2024

How Generalizable Are Findings from a Community-Based Prospective Cohort Study? Extending Estimates from the Adult Changes in Thought Study to Its Source Population.

Laura E Gibbons, Taylor Mobley, Elizabeth Rose Mayeda, Cecilia S Lee, Nicole M Gatto, Andrea Z LaCroix, Linda K McEvoy, Paul K Crane, Eleanor Hayes-Larson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Laura E GibbonsDepartment of Medicine, University of Washington, Seattle, WA, USA.
Taylor MobleyDepartment of Epidemiology, UCLA Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Elizabeth Rose MayedaDepartment of Epidemiology, UCLA Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Cecilia S LeeDepartment of Ophthalmology, University of Washington, Seattle, WA, USA.
Nicole M GattoKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Andrea Z LaCroixHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
Linda K McEvoyKaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, WA, USA.
Eleanor Hayes-LarsonDepartment of Epidemiology, UCLA Fielding School of Public Health, University of California, Los Angeles, CA, USA.

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Paul K Crane, Andrea Z. LaCroix · 2021 to 2026
$80.4M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
Aging eyes and aging brains in studying alzheimer's disease: Modern ophthalmic data collection in the adult changes in thought (ACT) studyR01AG060942 · NIA · WASHINGTON UNIVERSITY · PI Cecilia Sungmin Lee · 2019 to 2026
$39.4M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Conference on Advanced Psychometric Methods in Cognitive Aging ResearchR13AG030995 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MUNGAS, DAN M. · 2008 to 2022
$620k
Optimizing generalizability of biomarker studies for Alzheimer’s disease and related dementias with epidemiologic toolsR56AG069126 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYEDA, ELIZABETH ROSE · 2021 to 2021
$583k
Effects of lifecourse traumatic stress on late-life cognitive decline, dementia, and neuroimaging biomarkersK99AG075317 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HAYES-LARSON, ELEANOR LOUISE · 2022 to 2023
$241k
NIA NIH HHS K99 AG075317NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG060942NIA NIH HHS R13 AG030995NIA NIH HHS R56 AG069126NIA NIH HHS U01 AG006781NIA NIH HHS U19 AG066567
6 · The paper itself

Abstract

Background: The Adult Changes in Thought (ACT) study is a cohort of Kaiser Permanente Washington members ages 65+ that began in 1994. Objective: We wanted to know how well ACT participants represented all older adults in the region, and how well ACT findings on eye disease and its relationship with Alzheimer's disease generalized to all older adults in the Seattle Metropolitan Region. Methods: We used participation weights derived from pooling ACT and Behavioral Risk Factor Surveillance System (BRFSS) data to estimate prevalences of common eye diseases and their associations with Alzheimer's disease incidence. Cox proportional hazards models accounted for age, education, smoking, sex, and APOE genotype. Confidence intervals for weighted analyses were bootstrapped to account for error in estimating the weights. Results: ACT participants were fairly similar to older adults in the region. The largest differences were more self-reported current cholesterol medication use in BRFSS and higher proportions with low education in ACT. Incorporating the weights had little impact on prevalence estimates for age-related macular degeneration or glaucoma. Weighted estimates were slightly higher for diabetic retinopathy (weighted 5.7% (95% Confidence Interval 4.3, 7.1); unweighted 4.1% (3.6, 4.6)) and cataract history (weighted 51.8% (49.6, 54.3); unweighted 48.6% (47.3, 49.9)). The weighted hazard ratio for recent diabetic retinopathy diagnosis and Alzheimer's disease was 1.84 (0.34, 4.29), versus 1.32 (0.87, 2.00) in unweighted ACT. Conclusions: Most, but not all, associations were similar after participation weighting. Even in community-based cohorts, extending inferences to broader populations may benefit from evaluation with participation weights.

Indexed as

Alzheimer DiseaseAgedAged, 80 and overBehavioral Risk Factor Surveillance SystemCohort StudiesEye DiseasesFemaleHumansMalePrevalenceProportional Hazards ModelsProspective StudiesResidence CharacteristicsWashingtonAlzheimer’s diseasebiasdementiaepidemiological research designeye diseasesgeneralizabilityintegrated health-care delivery systemsprevalencetransportability

Identifiers

PMID38848188
PMCPMC11423796

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.