ArticleScience immunology2024
Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells.
Abstract read
In one paragraph
Article in Science immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Human iPSC-derived alveolar macrophages reveal macrophage subtype functions of itaconate in M. tuberculosis defense.JCI insight · 2026Article
- Remodeling the tumor immune microenvironment: mechanisms of crosstalk between regulated cell death macrophages.Frontiers in immunology · 2026Review
- Complement-mediated ADCP as a distinct and finite cytotoxic mechanism of monoclonal antibodies.Frontiers in immunology · 2026Article
- PAK2-driven cytoskeleton-endosome dynamics control macrophage hyperphagia and SIRPA engagement.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth.bioRxiv : the preprint server for biology · 2025Article
- Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma.Cancer research · 2025Article
- A crosstalk between adhesion and phagocytosis integrates macrophage functions into their microenvironment.iScience · 2025Article
- AI-based hardware and software tools in microscopy to boost research in immunology and virology.Frontiers in immunology · 2025Review
- Biochemical and biophysical mechanisms macrophages use to tune phagocytic appetite.Journal of cell science · 2025Review
- Neutrophil diversity and function in health and disease.Signal transduction and targeted therapy · 2024Review
- Transient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity.Brain, behavior, and immunity · 2024Article
- Follow the flow: Actin and membrane act as an integrated system to globally coordinate cell shape and movement.Current opinion in cell biology · 2024Review
Corrections and comments
- Update of
Authors and funding
21 authors.
Benjamin Y WinerImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-7895-2544
Alexander H SettleImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-5924-6994
Alexandrina M YakimovImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Carlos JeronimoImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tomi LazarovImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6312-0080
Murray TippingMolecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-5262-2723
Michelle SaoiDonald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Anjelique SawhNew York Structural Biology Center, New York, NY, USA.ORCID 0000-0001-8649-7246
Anna-Liisa L SeppDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Michael GalianoMolecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-4414-0358
Justin S A PerryImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-4063-6524
Yung Yu WongImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Frederic GeissmannImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-5029-2468
Justin CrossDonald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6356-057X
Ting ZhouCenter for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0003-1423-1507
Lance C KamDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID 0000-0001-6812-4956
H Amalia PasolliElectron Microscopy Resource Center, Rockefeller University, New York, NY, USA.ORCID 0000-0003-3899-3530
Tobias HohlHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-9097-5412
Jason G CysterDepartment of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-4735-9745
Orion D WeinerCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-1778-6543
Morgan HuseImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-9941-7719
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MCellular Decision Making Diversity SupplementR35GM118167 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Orion D Weiner · 2016 to 2026
$10.3MChemokines and Lymphoid Tissue Organization and FunctionR01AI045073 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1999 to 2023
$7.6MSynaptic Control of Cytotoxic T cell FunctionR01AI087644 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI HUSE, MORGAN A · 2010 to 2025
$7.3MMacrophage development and specification in mice.R01AI130345 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Frederic Geissmann · 2017 to 2026
$5.7MRole of Microglia Somatic Variants in Neurodegenerative DiseasesR01NS115715 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI GEISSMANN, FREDERIC · 2019 to 2023
$5.0MTri-I Training Program in MetabolomicsR25AI140472 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Kyu Y Rhee · 2019 to 2026
$2.4MChemokines and Lymphoid Tissue Organization and FunctionR37AI045073 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jason G Cyster · 2024 to 2026
$1.7MNCI NIH HHS P30 CA008748NIAID NIH HHS R01 AI045073NIAID NIH HHS R01 AI087644NIAID NIH HHS R01 AI130345NIAID NIH HHS R25 AI140472NIAID NIH HHS R37 AI045073NIGMS NIH HHS R35 GM118167NINDS NIH HHS R01 NS115715
Abstract
Professional phagocytes like neutrophils and macrophages tightly control what they consume, how much they consume, and when they move after cargo uptake. We show that plasma membrane abundance is a key arbiter of these cellular behaviors. Neutrophils and macrophages lacking the G protein subunit Gβ
Indexed as
Cell MembraneMice, KnockoutPhagocytosisAnimalsMacrophagesMiceMice, Inbred C57BLMyeloid CellsNeutrophils
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What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.