Evidence map›Paper›PMID 38849425›Full record

ArticleScientific reports2024

Double-modified, thio and methylene ATP analogue facilitates wound healing in vitro and in vivo.

Roza Pawlowska, Ewa Radzikowska-Cieciura, Sepideh Jafari, Julia Fastyn, Eliza Korkus, Edyta Gendaszewska-Darmach, Gangyin Zhao, Ewa Snaar-Jagalska, Arkadiusz Chworos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Mechanisms and therapeutic insights from zebrafish models of wound healing.Frontiers in cell and developmental biology · 2026
    Review
  2. Article
  3. P2YInternational journal of molecular sciences · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Roza PawlowskaCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363, Lodz, Poland. roza.pawlowska@cbmm.lodz.pl.
Ewa Radzikowska-CieciuraCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363, Lodz, Poland.
Sepideh JafariCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363, Lodz, Poland.
Julia FastynCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363, Lodz, Poland.
Eliza KorkusInstitute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Stefanowskiego 2/22, 90-537, Lodz, Poland.
Edyta Gendaszewska-DarmachInstitute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Stefanowskiego 2/22, 90-537, Lodz, Poland.
Gangyin ZhaoInstitute of Biology, Leiden University, 2333 BE, Leiden, The Netherlands.
Ewa Snaar-JagalskaInstitute of Biology, Leiden University, 2333 BE, Leiden, The Netherlands.
Arkadiusz ChworosCentre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363, Lodz, Poland.

Funding

National Science Centre in Poland 2017/26/D/ST5/01046National Science Centre in Poland 2023/49/B/ST4/03288
6 · The paper itself

Abstract

Recent data indicate that extracellular ATP affects wound healing efficacy via P2Y2-dependent signaling pathway. In the current work, we propose double-modified ATP analogue-alpha-thio-beta,gamma-methylene-ATP as a potential therapeutic agent for a skin regeneration. For the better understanding of structure-activity relationship, beside tested ATP analogues, the appropriate single-modified derivatives of target compound, such as alpha-thio-ATP and beta,gamma-methylene-ATP, were also tested in the context of their involvement in the activation of ATP-dependent purinergic signaling pathway via the P2Y2 receptor. The diastereomerically pure alpha-thio-modified-ATP derivatives were obtained using the oxathiaphospholane method as separate S

Indexed as

Adenosine TriphosphateKeratinocytesWound HealingZebrafishAnimalsCalciumCell LineCell MovementCell SurvivalHumansMolecular Docking SimulationReceptors, Purinergic P2Y2Signal TransductionStructure-Activity RelationshipAdenosine TriphosphateCalciumReceptors, Purinergic P2Y2ATP analogueP2Y2 receptorPurinergic signalingSkin regenerationWound healing

Identifiers

PMID38849425
PMCPMC11161507

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.