Evidence map›Paper›PMID 38849433›Full record

ArticleScientific reports2024

Cell-specific models of hiPSC-CMs developed by the gradient-based parameter optimization method fitting two different action potential waveforms.

Yixin Zhang, Futoshi Toyoda, Yukiko Himeno, Akinori Noma, Akira Amano

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yixin ZhangGraduate School of Life Sciences, Ritsumeikan University, Kusatsu, Japan.
Futoshi ToyodaDepartment of Physiology, Shiga University of Medical Science, Otsu, Japan.
Yukiko HimenoGraduate School of Life Sciences, Ritsumeikan University, Kusatsu, Japan. hime@fc.ritsumei.ac.jp.
Akinori NomaGraduate School of Life Sciences, Ritsumeikan University, Kusatsu, Japan.
Akira AmanoGraduate School of Life Sciences, Ritsumeikan University, Kusatsu, Japan.

Funding

Japan Society for the Promotion of Science 16K18996Japan Society for the Promotion of Science 21K06781
6 · The paper itself

Abstract

Parameter optimization (PO) methods to determine the ionic current composition of experimental cardiac action potential (AP) waveform have been developed using a computer model of cardiac membrane excitation. However, it was suggested that fitting a single AP record in the PO method was not always successful in providing a unique answer because of a shortage of information. We found that the PO method worked perfectly if the PO method was applied to a pair of a control AP and a model output AP in which a single ionic current out of six current species, such as I

Indexed as

Action PotentialsInduced Pluripotent Stem CellsMyocytes, CardiacComputer SimulationHumansModels, Cardiovascular

Identifiers

PMID38849433
PMCPMC11161598

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.