Evidence map›Paper›PMID 38850447›Full record

ArticleJournal of molecular histology2024

Zinc-alkaline phosphatase at sites of aortic calcification.

Santiago Gomez, José Luis Millán

Erratum issuedAbstract read
In one paragraph

Article in Journal of molecular histology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Santiago GomezDepartamento Anatomía Patológica, Facultad de Medicina, Universidad de Cádiz, Plaza Fragela 9, Cádiz, 11003, Spain. santiago.gomez@uca.es.ORCID http://orcid.org/0000-0002-3156-0989
José Luis MillánSanford Children's Health Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1547-2671

Funding

Project 4 - Mechanisms of pyrophosphate dysregulationP01AG081167 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI Francesca M Marassi · 2023 to 2026
$13.0M
Instituto de Salud Carlos III G03-122NIA NIH HHS AG081167NIA NIH HHS P01 AG081167
6 · The paper itself

Abstract

Zinc (Zn) is a normal trace element in mineralizing tissues, but it is unclear whether it is primarily bound to the mineral phase or to organic molecules involved in the mineralization process, or both. Tissue-nonspecific alkaline phosphatase (TNAP) is a Zn metalloenzyme with two Zn ions bound to the M1 and M2 catalytic sites that functions to control the phosphate/pyrophosphate ratio during biomineralization. Here, we studied aortas from Tagln-Cre

Indexed as

Alkaline PhosphataseAortaZincAnimalsCalcinosisCalciumMiceRatsVascular CalcificationAlkaline PhosphataseCalciumZincAlkaline phosphataseAortaCalcificationCartilageZinc

Identifiers

PMID38850447
PMCPMC11306377

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.