Evidence map›Paper›PMID 38851817›Full record

ArticleCommunications biology2024

Sirtuin E deacetylase is required for full virulence of Aspergillus fumigatus.

Natália S Wassano, Gabriela B da Silva, Artur H Reis, Jaqueline A Gerhardt, Everton P Antoniel, Daniel Akiyama, Caroline P Rezende, Leandro X Neves, Elton J R Vasconcelos, Fernanda L de Figueiredo and 8 more

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Engineering of Global Transcriptional Regulators (GTRs) inJournal of fungi (Basel, Switzerland) · 2025
    Review
  5. Review
  6. Article
  7. Journal of fungi (Basel, Switzerland) · 2025
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Natália S WassanoDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
Gabriela B da SilvaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
Artur H ReisDepartment of Microbiology, Immunology and Parasitology, Paulist School of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Jaqueline A GerhardtDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
Everton P AntonielDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
Daniel AkiyamaDepartment of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil.ORCID 0000-0003-2859-1992
Caroline P RezendeDepartment of Biochemistry and Immunology, Faculty of Medicine from Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Leandro X NevesBrazilian Bioscience National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil.ORCID 0000-0002-6074-1025
Elton J R VasconcelosLeeds Omics, Faculty of Biological Sciences, University of Leeds, Leeds, UK.ORCID 0000-0001-5130-6622
Fernanda L de FigueiredoDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
Fausto AlmeidaDepartment of Biochemistry and Immunology, Faculty of Medicine from Ribeirão Preto, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-3782-3698
Patrícia A de CastroFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Camila F PinzanFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Gustavo H GoldmanNational Institute of Science and Technology in Human Pathogenic Fungi, Ribeirão Preto, Brazil.ORCID 0000-0002-2986-350X
Adriana F Paes LemeBrazilian Bioscience National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Brazil.ORCID 0000-0001-7959-147X
Taicia P FillNational Institute of Science and Technology in Human Pathogenic Fungi, Ribeirão Preto, Brazil.
Nilmar S MorettiDepartment of Microbiology, Immunology and Parasitology, Paulist School of Medicine, Federal University of São Paulo, São Paulo, Brazil. nilmar.moretti@unifesp.br.ORCID 0000-0003-0455-2497
André DamasioDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil. adamasio@unicamp.br.ORCID 0000-0001-9304-3998

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research Foundation) 2018/09948-0Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research Foundation) 2020/06151-4Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research Foundation) 2021/04977-5Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research Foundation) 2022/02992-0Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo Research Foundation) 2022/03075-0
6 · The paper itself

Abstract

Aspergillus fumigatus represents a public health problem due to the high mortality rate in immunosuppressed patients and the emergence of antifungal-resistant isolates. Protein acetylation is a crucial post-translational modification that controls gene expression and biological processes. The strategic manipulation of enzymes involved in protein acetylation has emerged as a promising therapeutic approach for addressing fungal infections. Sirtuins, NAD

Indexed as

AspergillosisAspergillus fumigatusSirtuinsAcetylationAnimalsFungal ProteinsGene Expression Regulation, FungalMiceMothsVirulenceVirulence FactorsFungal ProteinsSirtuinsVirulence Factors

Identifiers

PMID38851817
PMCPMC11162503

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.