Evidence map›Paper›PMID 38854152›Full record

ArticlebioRxiv : the preprint server for biology2024

Semaphorin Receptors Antagonize Wnt Signaling Through Beta-Catenin Degradation.

Tyler M Hoard, Katie Liu, Kenneth M Cadigan, Roman J Giger, Benjamin L Allen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tyler M HoardDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
Katie LiuDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
Kenneth M CadiganDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA.
Roman J GigerDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-2926-3336
Benjamin L AllenDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-2323-8313

Funding

Inhibitors of Synaptogenesis and Mental HealthR01MH119346 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GIGER, ROMAN JENO · 2019 to 2023
$2.6M
Investigating GLI transcription factors as regulators of the pancreatic cancer microenvironmentR01CA275182 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Benjamin Allen, Marina Pasca Di Magliano · 2023 to 2026
$2.4M
NCI NIH HHS R01 CA275182NIMH NIH HHS R01 MH119346
6 · The paper itself

Abstract

Precise control of morphogen signaling levels is essential for proper development. An outstanding question is: what mechanisms ensure proper morphogen activity and correct cellular responses? Previous work has identified Semaphorin (SEMA) receptors, Neuropilins (NRPs) and Plexins (PLXNs), as positive regulators of the Hedgehog (HH) signaling pathway. Here, we provide evidence that NRPs and PLXNs antagonize Wnt signaling in both fibroblasts and epithelial cells. Further,

Indexed as

Beta-CateninHedgehogNeuropilinPlexinSemaphorinWnt

Identifiers

PMID38854152
PMCPMC11160715

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.