ArticleBiomedical optics express2024
In-vivo characterization of scleral rigidity in myopic eyes using fundus-pulsation optical coherence elastography.
Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed.
- Ocular rigidity in eyes with experimental myopia.Experimental eye research · 2026Article
- Association between ocular biometric parameters and scleral rigidity as measured by fundus pulsation optical coherence elastography in eyes with and without glaucoma.Frontiers in medicine · 2026Article
- Quantitative assessment of retinal attenuation and backscattering in OCT imaging using iterative layer-based analysis.Biomedical optics express · 2025Article
- Air-pulse optical coherence elastography: how excitation angle affects mechanical wave propagation.Biomedical optics express · 2025Article
- Axial length association with corneoscleral sagittal height and scleral asymmetry.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Observational
- Chirp excitation for natural frequency optical coherence elastography.Biomedical optics express · 2024Article
- Choroidal vascular changes in early-stage myopic maculopathy from deep learning choroidal analysis: a hospital-based SS-OCT study.Eye and vision (London, England) · 2024Article
- From stress to sight: The role of mechanical forces in the retinal diseases.Advances in ophthalmology practice and researchReview
- Research progress of in vivo measurement methods of myopia sclera biomechanics.Advances in ophthalmology practice and researchReview
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sclera plays an important role in the structural integrity of the eye. However, as myopia progresses, the elongation of the eyeball exerts stretching forces on the posterior sclera, which typically happens in conjunction with scleral remodeling that causes rigidity loss. These biomechanical alterations can cause localized eyeball deformation and vision impairment. Therefore, monitoring scleral rigidity is clinically important for the management and risk assessment of myopia. In this study, we propose fundus pulsation optical coherence elastography (FP-OCE) to characterize posterior scleral rigidity in living humans. This methodology is based on a choroidal pulsation model, where the scleral rigidity is inversely associated with the choroidal max strain obtained through phase-sensitive optical coherence tomography (PhS-OCT) measurement of choroidal deformation and thickness. Using FP-OCE, we conducted a pilot clinical study to explore the relationship between choroidal strain and myopia severity. The results revealed a significant increase in choroidal max strain in pathologic myopia, indicating a critical threshold beyond which scleral rigidity decreases significantly. Our findings offer a potential new method for monitoring myopia progression and evaluating therapies that alter scleral mechanical properties.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.