Evidence map›Paper›PMID 38856235›Full record

ArticlemSystems2024

A simple BLASTn-based approach generates novel insights into the regulation and biological function of type I toxin-antitoxins.

Selene F H Shore, Michael Ptacek, Andrew D Steen, Elizabeth M Fozo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Selene F H ShoreDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Michael PtacekDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
Andrew D SteenDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0003-4297-4332
Elizabeth M FozoDepartment of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.ORCID 0000-0002-6928-2275

Funding

T-COHR: Training in Craniofacial and Oral Health ResearchT32DE017551 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAO, HAI · 2006 to 2025
$10.3M
Small proteins in sugar metabolismR15GM106291 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI FOZO, ELIZABETH M. · 2014 to 2014
$329k
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R15GM106291NIDCR NIH HHS T32 DE017551NIGMS NIH HHS R15 GM106291University of Tennessee, Knoxville (UT) Student Faculty Research Award
6 · The paper itself

Abstract

Bacterial chromosomal type I toxin-antitoxin systems consist of a small protein, typically under 60 amino acids, and a small RNA (sRNA) that represses toxin translation. These gene pairs have gained attention over the last decade for their contribution to antibiotic persistence and phage tolerance in bacteria. However, biological functions for many remain elusive as gene deletions often fail to produce an observable phenotype. For many pairs, it is still unknown when the toxin and/or antitoxin gene are natively expressed within the bacterium. We examined sequence conservation of three type I toxin-antitoxin systems,

Indexed as

Escherichia coliEscherichia coli ProteinsToxin-Antitoxin SystemsBacterial ToxinsGene Expression Regulation, BacterialBacterial ToxinsEscherichia coli ProteinsorzOshoBsRNAtisBtoxin-antitoxintype I toxinzorO

Identifiers

PMID38856235
PMCPMC11264685

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.