Evidence mapPaperPMID 38858593Full record

ArticleNature microbiology2024

Phytate metabolism is mediated by microbial cross-feeding in the gut microbiota.

Willem M De Vos, Minh Nguyen Trung, Mark Davids, Guizhen Liu, Melany Rios-Morales, Henning Jessen, Dorothea Fiedler, Max Nieuwdorp, Thi Phuong Nam Bui

Abstract read
In one paragraph

Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. NovelGut · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Food chemistry: X · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Willem M De Vos *Laboratory of Microbiology, Wageningen University, Wageningen, the Netherlands.ORCID http://orcid.org/0000-0002-0273-3166
Minh Nguyen Trung *Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID http://orcid.org/0000-0003-3100-9609
Mark DavidsDepartments of Internal and Experimental Vascular Medicine, Amsterdam University Medical Center, Location AMC, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-3081-9124
Guizhen LiuInstitute of Organic Chemistry & Centre for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, Freiburg, Germany.
Melany Rios-MoralesDepartments of Internal and Experimental Vascular Medicine, Amsterdam University Medical Center, Location AMC, Amsterdam, the Netherlands.
Henning JessenInstitute of Organic Chemistry & Centre for Integrative Biological Signaling Studies (CIBSS), University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-1025-9484
Dorothea FiedlerLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID http://orcid.org/0000-0002-0798-946X
Max NieuwdorpDepartments of Internal and Experimental Vascular Medicine, Amsterdam University Medical Center, Location AMC, Amsterdam, the Netherlands.
Thi Phuong Nam BuiLaboratory of Microbiology, Wageningen University, Wageningen, the Netherlands. t.p.n.bui@amsterdamumc.nl.ORCID http://orcid.org/0000-0001-5366-5960

Funding

Dutch Research Council 024.002.002ZonMw 09150162210057ZonMw 09150182010020
6 · The paper itself

Abstract

Dietary intake of phytate has various reported health benefits. Previous work showed that the gut microbiota can convert phytate to short-chain fatty acids (SCFAs), but the microbial species and metabolic pathway are unclear. Here we identified Mitsuokella jalaludinii as an efficient phytate degrader, which works synergistically with Anaerostipes rhamnosivorans to produce the SCFA propionate. Analysis of published human gut taxonomic profiles revealed that Mitsuokella spp., in particular M. jalaludinii, are prevalent in human gut microbiomes. NMR spectroscopy using

Indexed as

Gastrointestinal MicrobiomePhytic AcidAnimalsCaco-2 CellsEubacterialesFatty Acids, VolatileHumansInositolMetabolic Networks and PathwaysMetabolomicsMiceMicrobial InteractionsPropionatesFatty Acids, VolatileInositolPhytic AcidPropionates

Identifiers

PMID38858593
PMCPMC7618129

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.