Evidence map›Paper›PMID 38860285›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2024

Modulation of intracellular calcium activity in interstitial cells of Cajal by inhibitory neural pathways within the internal anal sphincter.

Karen I Hannigan, Emer P Ni Bhraonain, Thomas W Gould, Kathleen D Keef, Caroline A Cobine

Abstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karen I HanniganDepartment of Physiology and Cell BiologyUniversity of NevadaRenoNevadaUnited States.ORCID 0000-0002-0091-0640
Emer P Ni BhraonainDepartment of Physiology and Cell BiologyUniversity of NevadaRenoNevadaUnited States.
Thomas W GouldDepartment of Physiology and Cell BiologyUniversity of NevadaRenoNevadaUnited States.
Kathleen D KeefDepartment of Physiology and Cell BiologyUniversity of NevadaRenoNevadaUnited States.
Caroline A CobineDepartment of Physiology and Cell BiologyUniversity of NevadaRenoNevadaUnited States.ORCID 0000-0002-2871-3825

Funding

Transgenic Animal Genotyping and Phenotyping CoreP20GM130459 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Yumei Feng Earley · 2019 to 2026
$20.3M
Control of motility in the internal anal sphincterR01DK078736 · NIDDK · UNIVERSITY OF NEVADA RENO · PI KEEF, KATHLEEN D · 2010 to 2019
$3.4M
Control of motility in the lower esophageal sphincterR01DK129528 · NIDDK · UNIVERSITY OF NEVADA RENO · PI COBINE, CAROLINE ANN · 2021 to 2025
$2.1M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK078736HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK129528HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM130459NIDDK NIH HHS R01 DK078736NIDDK NIH HHS R01 DK129528NIGMS NIH HHS P20 GM130459
6 · The paper itself

Abstract

The internal anal sphincter (IAS) functions to maintain continence. Previous studies utilizing mice with cell-specific expression of GCaMP6f revealed two distinct subtypes of intramuscular interstitial cells of Cajal (ICC-IM) with differing Ca

Indexed as

Anal CanalCalciumInterstitial Cells of CajalAnimalsCalcium SignalingElectric StimulationMiceMyocytes, Smooth MuscleNitric OxideCalciumNitric Oxidegastrointestinalinositol (1,4,5)-trisphosphate receptor-associated cGMP kinase substrate Imotilitynitrergicpurinergic

Identifiers

PMID38860285
PMCPMC11427099

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.