Evidence map›Paper›PMID 38860764›Full record

ArticlemBio2024

IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway.

Eileen A Moran, Karen Salas-Briceno, Wenming Zhao, Takuji Enya, Alexya N Aguilera, Ivan Acosta, Francis Alonzo, Dara Kiani, Judith Behnsen, Catalina Alvarez and 4 more

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eileen A Moran *Department of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.
Karen Salas-Briceno *Department of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.
Wenming Zhao *Department of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.
Takuji Enya *Department of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.
Alexya N AguileraDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.
Ivan AcostaDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.
Francis AlonzoDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.ORCID 0000-0001-8445-4218
Dara KianiDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-4582-7138
Judith BehnsenDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.ORCID 0000-0003-0109-1090
Catalina AlvarezGulbenkian Institute of Science, Oeiras, Portugal.
Thomas M KeaneEMBL-EBI, Wellcome Genome Campus, Cambridge, United Kingdom.
David J AdamsWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom.
Jingtao LilueGulbenkian Institute of Science, Oeiras, Portugal.ORCID 0000-0002-1958-0231
Susan R RossDepartment of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-3094-3769

Funding

Role of DNA sensors in host anti-retroviral defenseR01AI121275 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ROSS, SUSAN R · 2016 to 2020
$2.0M
Interplay between reverse transcription and host restrictionR01AI174538 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ROSS, SUSAN R · 2023 to 2025
$1.6M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 1R01AI174538HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI121275NIAID NIH HHS R01 AI121275NIAID NIH HHS R01 AI174538
6 · The paper itself

Abstract

Mammalian AIM-2-like receptor (ALR) proteins bind nucleic acids and initiate production of type I interferons or inflammasome assembly, thereby contributing to host innate immunity. In mice, the

Indexed as

Membrane ProteinsVirus ReplicationAnimalsEvolution, MolecularHost-Pathogen InteractionsImmunity, InnateLeukemia Virus, MurineMiceMice, Inbred C57BLNuclear ProteinsSTING ProteinMembrane ProteinsNuclear ProteinsSting1 protein, mouseSTING ProteinAIM-2-like receptorevolution of gene functionnucleic acid sensorviral immunity

Identifiers

PMID38860764
PMCPMC11253629

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.