Evidence map›Paper›PMID 38860856›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2024

Colonocyte keratins stabilize mitochondria and contribute to mitochondrial energy metabolism.

Joel H Nyström, Taina R H Heikkilä, Keshav Thapa, Ilari Pulli, Kid Törnquist, Diana M Toivola

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Joel H NyströmCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.ORCID 0000-0002-3514-6064
Taina R H HeikkiläCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Keshav ThapaCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Ilari PulliCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Kid TörnquistCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Diana M ToivolaCell Biology, Biosciences, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.

Funding

Abo Akademi UniversityAbo Akademi University Centers of Excellence of Cell Stress and Molecular Aging and Cellular MechanostasisEU FP7 IRGEuropean Cooperation in Science and Technology (COST) CA15214K. Albin Johanssons Stiftelse (K. Albin Johansson Foundation)Magnus Ehrnroothin Säätiö (Magnus Ehrnrooth Foundation)Makarna Agneta och Carl-Erik Olins FoundationMary och Georg C. Ehrnrooths Stiftelse (Mary ja Georg C. Ehrnroothin Säätiö)Medicinska Understödsföreningen Liv och Hälsa (Medicinska Understödsföreningen Liv och Hälsa r.f.)Otto A. Malm Lahjoitusrahasto (Otto A. Malm Foundation)Paulon Säätiö (Paulo Foundation)Research Council of Finland (AKA) 140759,126161,332582 and 315139Sigrid Juséliuksen Säätiö (Sigrid Jusélius Stiftelse)Svenska Kulturfonden (Svenska Kulturfondenista)The InFLAMES Research Flagship Programme 337531 and 357911Turku Doctoral Programme in Molecular Biosciences at Åbo Akademi UniversityVictoriastiftelsen (Victoria Foundation)Waldemar von Frenckells Stiftelse (Waldemar von Frenckell Foundation)
6 · The paper itself

Abstract

Keratin intermediate filaments form dynamic filamentous networks, which provide mechanical stability, scaffolding, and protection against stress to epithelial cells. Keratins and other intermediate filaments have been increasingly linked to the regulation of mitochondrial function and homeostasis in different tissues and cell types. While deletion of keratin 8 (K8

Indexed as

ColonEnergy MetabolismKeratin-8Mice, KnockoutMitochondriaAnimalsCaco-2 CellsEnterocytesGTP PhosphohydrolasesHumansMembrane Potential, MitochondrialMiceMitochondrial ProteinsProhibitinsRepressor ProteinsGTP PhosphohydrolasesKeratin-8Krt8 protein, mouseMfn2 protein, mouseMitochondrial ProteinsPhb2 protein, mouseProhibitinsRepressor Proteinscolonenergy metabolisminflammatory bowel diseaseskeratinsmitochondria

Identifiers

PMID38860856
PMCPMC11427106

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.