Evidence map›Paper›PMID 38863574›Full record

ArticleBrain communications2024

Genome-wide meta-analysis of short-tandem repeats for Parkinson's disease risk using genotype imputation.

Olena Ohlei, Kimberly Paul, Susan Searles Nielsen, David Gmelin, Valerija Dobricic, Vivian Altmann, Marcel Schilling, Jeff M Bronstein, Andre Franke, Michael Wittig and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Olena OhleiLübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, 23562 Lübeck, Germany.
Kimberly PaulDepartment of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Susan Searles NielsenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA.
David GmelinLübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, 23562 Lübeck, Germany.
Valerija DobricicLübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, 23562 Lübeck, Germany.
Vivian AltmannLübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, 23562 Lübeck, Germany.
Marcel SchillingLübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, 23562 Lübeck, Germany.
Jeff M BronsteinDepartment of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, 24105 Kiel, Germany.
Michael WittigInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, 24105 Kiel, Germany.ORCID https://orcid.org/0000-0003-1103-4196
Laura ParkkinenNuffield Department of Clinical Neurosciences, Oxford Parkinson's Disease Centre, University of Oxford, Oxford OX1 3PT, UK.
Johnni HansenDanish Cancer Institute, Danish Cancer Society, 2100 Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-9342-2725
Harvey CheckowayHerbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA 92093, USA.
Beate RitzDepartment of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.ORCID https://orcid.org/0000-0001-6976-7339
Lars BertramLübeck Interdisciplinary Platform for Genome Analytics (LIGA), University of Lübeck, 23562 Lübeck, Germany.ORCID https://orcid.org/0000-0002-0108-124X
Christina M LillInstitute of Epidemiology and Social Medicine, University of Münster, 48149 Münster, Germany.ORCID https://orcid.org/0000-0002-2805-1307

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Nicole Ann Errett · 1995 to 2026
$42.5M
PARKINSON'S DISEASES SUSCEPTIBILITY GENES AND PESTICIDESR01ES010544 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2000 to 2015
$5.7M
Registry Study of Parkinsons Disease in DenmarkR01ES013717 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2006 to 2010
$4.5M
NIEHS NIH HHS P30 ES007033NIEHS NIH HHS R01 ES010544NIEHS NIH HHS R01 ES013717
6 · The paper itself

Abstract

Idiopathic Parkinson's disease is determined by a combination of genetic and environmental factors. Recently, the first genome-wide association study on short-tandem repeats in Parkinson's disease reported on eight suggestive short-tandem repeat-based risk loci (

Indexed as

DNA methylationgenome-wide association studymicrosatellitesParkinson’s diseaseshort-tandem repeats

Identifiers

PMID38863574
PMCPMC11166220

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.