Evidence map›Paper›PMID 38864742›Full record

ArticleRadiology. Artificial intelligence2024

Reproducibility Analysis of Radiomic Features on T2-weighted MR Images after Processing and Segmentation Alterations in Neuroblastoma Tumors.

Diana Veiga-Canuto, Matías Fernández-Patón, Leonor Cerdà Alberich, Ana Jiménez Pastor, Armando Gomis Maya, Jose Miguel Carot Sierra, Cinta Sangüesa Nebot, Blanca Martínez de Las Heras, Ulrike Pötschger, Sabine Taschner-Mandl and 6 more

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Article in Radiology. Artificial intelligence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
–field-weighted citation impact
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6 citing papers in PubMed.

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5 · Who and what money

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16 authors.

Diana Veiga-CanutoFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).ORCID 0000-0002-6048-2940
Matías Fernández-PatónFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).ORCID 0000-0001-9374-1411
Leonor Cerdà AlberichFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).
Ana Jiménez PastorFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).ORCID 0000-0002-0978-9429
Armando Gomis MayaFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).ORCID 0000-0002-9527-8093
Jose Miguel Carot SierraFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).ORCID 0000-0001-6524-1639
Cinta Sangüesa NebotFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).
Blanca Martínez de Las HerasFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).
Ulrike PötschgerFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).
Sabine Taschner-MandlFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).ORCID 0000-0002-1439-5301
Emanuele NeriFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).ORCID 0000-0001-7950-4559
Adela CañeteFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).ORCID 0000-0002-5669-5097
Ruth LadensteinFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).
Barbara HeroFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).
Ángel Alberich-BayarriFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).ORCID 0000-0002-5932-2392
Luis Martí-BonmatíFrom the Grupo de Investigación Biomédica en Imagen, Instituto de Investigación Sanitaria La Fe, Avenida Fernando Abril Martorell, 106 Torre A planta 7, 46026 Valencia, Spain (D.V.C., M.F.P., L.C.A., A.G.M., L.M.B.); Área Clínica de Imagen Médica (D.V.C., C.S.N., L.M.B.) and Department of Pediatric Oncology (B.M.d.l.H., A.C.), Hospital Universitari i Politècnic La Fe, Valencia, Spain; Quantitative Imaging Biomarkers in Medicine, QUIBIM SL, Valencia, Spain (A.J.P., A.A.B.); Departamento de Estadística e Investigación Operativa Aplicadas y Calidad, Universitat Politècnica de València, Valencia, Spain (J.M.C.S.); St. Anna Children's Cancer Research Institute, Vienna, Austria (U.P., S.T.M., R.L.); Division of Academic Radiology, Department of Translational Research, University of Pisa, Pisa, Italy (E.N.); and Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical 18 Faculty, University of Cologne, Cologne, Germany (B.H.).ORCID 0000-0002-8234-010X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose To evaluate the reproducibility of radiomics features extracted from T2-weighted MR images in patients with neuroblastoma. Materials and Methods A retrospective study included 419 patients (mean age, 29 months ± 34 [SD]; 220 male, 199 female) with neuroblastic tumors diagnosed between 2002 and 2023, within the scope of the PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers (ie, PRIMAGE) project, involving 746 T2/T2*-weighted MRI sequences at diagnosis and/or after initial chemotherapy. Images underwent processing steps (denoising, inhomogeneity bias field correction, normalization, and resampling). Tumors were automatically segmented, and 107 shape, first-order, and second-order radiomics features were extracted, considered as the reference standard. Subsequently, the previous image processing settings were modified, and volumetric masks were applied. New radiomics features were extracted and compared with the reference standard. Reproducibility was assessed using the concordance correlation coefficient (CCC); intrasubject repeatability was measured using the coefficient of variation (CoV). Results When normalization was omitted, only 5% of the radiomics features demonstrated high reproducibility. Statistical analysis revealed significant changes in the normalization and resampling processes (

Indexed as

Magnetic Resonance ImagingNeuroblastomaChildChild, PreschoolFemaleHumansImage Interpretation, Computer-AssistedInfantMaleRadiomicsReproducibility of ResultsRetrospective StudiesMR ImagingNeuroblastic TumorsOncologyPediatricsRadiomicsRepeatabilityReproducibility

Identifiers

PMID38864742
PMCPMC11294951

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