Evidence map›Paper›PMID 38864946›Full record

ArticleArchives of virology2024

Replacement of P1 of soybean mosaic virus with P1 of clover yellow vein virus has no impact on virus viability and host specificity.

Joon Kwon, Rongbin Hu, Amanda K Penicks, Chunyu Zhang, Yongzhi Wang, David Lohry, Elias J Fernandez, Leslie L Domier, M R Hajimorad

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joon KwonDepartment of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, 37996, USA.
Rongbin HuDepartment of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, 37996, USA.
Amanda K PenicksDepartment of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, 37996, USA.
Chunyu ZhangJilin Academy of Agricultural Sciences, Changchun, 130033, Jilin, China.
Yongzhi WangJilin Academy of Agricultural Sciences, Changchun, 130033, Jilin, China.
David LohryDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, 39316, USA.
Elias J FernandezDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, 39316, USA.
Leslie L DomierSoybean/Maize Germplasm, Pathology, and Genetics Research Unit, USDA-ARS, Urbana, IL, 61801, USA.
M R HajimoradDepartment of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, 37996, USA. mrh@utk.edu.ORCID http://orcid.org/0000-0002-8006-2572

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Potyvirus genomes are expressed as polyproteins that are autocatalytically cleaved to produce 10 to 12 multifunctional proteins, among which P1 is the most variable. It has long been hypothesized that P1 plays role(s) in host adaptation and host specificity. We tested this hypothesis using two phylogenetically distinct potyviruses: soybean mosaic virus (SMV), with a narrow host range, and clover yellow vein virus (ClYVV), with a broader host range. When the full-length P1 cistron of SMV-N was replaced with P1 from ClYVV-No.30, the chimera systemically infected only SMV-N-permissive hosts. Hence, there were no changes in the host range or host specificity of the chimeric viruses. Despite sharing only 20.3% amino acid sequence identity, predicted molecular models of P1 proteins from SMV-N and ClYVV-No.30 showed analogous topologies. These observations suggest that P1 of ClYVV-No.30 can functionally replace P1 of SMV-N. However, the P1 proteins of these two potyviruses are not determinants of host specificity and host range.

Indexed as

Host SpecificityPlant DiseasesPotyvirusViral ProteinsGlycine maxNicotianaPhylogenyP1 protein, potyvirusViral ProteinsHost adaptationPlant virusesPotyvirusesRecombinantRNA viruses

Identifiers

PMID38864946

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.