Evidence map›Paper›PMID 38864979›Full record

SynthesisActa diabetologica2024

Effectiveness of different advanced wound dressings versus standard of care for the management of diabetic foot ulcers: a meta-analysis of randomized controlled trials for the development of the Italian guidelines for the treatment of diabetic foot syndrome.

Matteo Monami, Benedetta Ragghianti, Alessia Scatena, Cesare Miranda, Luca Monge, Luigi Uccioli, Laura Stefanon, Cristina Cappella, Antonio Silverii, Cristiana Vermigli and 1 more

Abstract readMeta-AnalysisComparative Study
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In one paragraph

Synthesis in Acta diabetologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matteo MonamiAzienda Ospedaliero Universitaria Careggi and University of Florence, Florence, Italy. matteo.monami@unifi.it.ORCID http://orcid.org/0000-0001-9349-828X
Benedetta RagghiantiAzienda Ospedaliero Universitaria Careggi and University of Florence, Florence, Italy.
Alessia ScatenaSan Donato Hospital, Health Authorities South East Tuscany, ArezzoArezzo, Italy.
Cesare MirandaPordenone Hospital, Pordenone, Italy.
Luca MongeAMD - Italian Association of Clinical Diabetologists, Rome, Italy.
Luigi UccioliDiabetes Section CTO Hospital and Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy.
Laura StefanonAzienda Sanitaria Friuli Occidentale, Pordenone, Italy.
Cristina CappellaUniversity Hospital Perugia, Perugia, Italy.
Antonio SilveriiAzienda Ospedaliero Universitaria Careggi and University of Florence, Florence, Italy.
Cristiana VermigliUniversity Hospital Perugia, Perugia, Italy.
Panel of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome and on behalf of SID and AMD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimto assess the effects of advanced wound dressings (AWD) commonly used in the treatment of predominantly neuropathic diabetic foot ulcers (DFU) The present meta-analysis was designed to support the development of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome (DFS).

methodsA Medline and Embase search were performed up to April 1st, 2024 collecting all RCTs including diabetic patients or reporting subgroup analyses on diabetic patients with DFU comparing AWD with placebo/standard of care (SoC), with a duration of at least 12 weeks. Prespecified endpoints were: ulcer healing (principal), time-to-healing, frequency of dressings change, major and minor amputation, pain, and all-cause mortality. AWD assessed were: alginates; foam, hydrocolloids, hydrogels, hyaluronic acid, hemoglobin spray, silver-impregnated, sucrose octasulfate-impregnated, honey-impregnated, micro-organism-binding, and protease-modulating matrix dressings. Mantel-Haenzel Odds ratios and 95% confidence intervals (MH-OR, 95% CIs) were either calculated or extracted directly from the publications. Weighted mean differences (WMD) and 95% CIs were calculated for continuous variables.

resultsFifteen studies fulfilled all inclusion criteria. Participants treated with AWD had a significantly higher ulcer healing rate and shorter time-to-healing in comparison with SoC/placebo (MH-OR 1.50 [0.80, 2.79], p = 0.20 and WMD:: - 24.38 [- 42.90, - 5.86] days, p = 0.010). No other significant effect on the above reported prespecified endpoints were observed. For the primary endpoint, the quality of evidence was rated as "moderate".

conclusionsIn conclusion, AWD, particularly sucrose-octasulfate, hydrogels, hyaluronic acid, and honey dressings, can actively promote wound healing and shortening time-to-healing in patients with DFU.

Indexed as

BandagesDiabetic FootStandard of CareWound HealingAmputation, SurgicalHoneyHumansHyaluronic AcidItalyPractice Guidelines as TopicRandomized Controlled Trials as TopicTreatment OutcomeHyaluronic AcidAdvanced wound dressingsDiabetic foot ulcersGuidelinesMeta-analysisUlcer healing

Identifiers

PMID38864979

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.