Evidence map›Paper›PMID 38865332›Full record

ArticleEuropean heart journal2024

Non-coding RNA yREX3 from human extracellular vesicles exerts macrophage-mediated cardioprotection via a novel gene-methylating mechanism.

Alessandra Ciullo, Liang Li, Chang Li, Kara Tsi, Colin Farrell, Matteo Pellegrini, Eduardo Marbán, Ahmed G E Ibrahim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Differentiation of mtDNA Methylation in Tissues of Ridgetail White Prawn,Animals : an open access journal from MDPI · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. MicroRNAs in diabetic macroangiopathy.Cardiovascular diabetology · 2024
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alessandra CiulloCedars-Sinai Medical Center, Smidt Heart Institute, 8700 Beverly Blvd, 1090 Davis Bldg, Los Angeles, CA 90048, USA.ORCID 0000-0002-8681-3883
Liang LiCedars-Sinai Medical Center, Smidt Heart Institute, 8700 Beverly Blvd, 1090 Davis Bldg, Los Angeles, CA 90048, USA.
Chang LiCedars-Sinai Medical Center, Smidt Heart Institute, 8700 Beverly Blvd, 1090 Davis Bldg, Los Angeles, CA 90048, USA.
Kara TsiCedars-Sinai Medical Center, Smidt Heart Institute, 8700 Beverly Blvd, 1090 Davis Bldg, Los Angeles, CA 90048, USA.
Colin FarrellDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-3138-6108
Matteo PellegriniDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-9355-9564
Eduardo MarbánCedars-Sinai Medical Center, Smidt Heart Institute, 8700 Beverly Blvd, 1090 Davis Bldg, Los Angeles, CA 90048, USA.ORCID 0000-0002-3863-280X
Ahmed G E IbrahimCedars-Sinai Medical Center, Smidt Heart Institute, 8700 Beverly Blvd, 1090 Davis Bldg, Los Angeles, CA 90048, USA.ORCID 0000-0002-1657-7432

Funding

PENSION AND SOCIAL SECURITY WEALTH IN THE HRSR01AG012751 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1995 to 1995
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California Institute for Regenerative Medicine EDUC4-12751National Heart Lung and Blood Institute R01 HL124074, R01 HL142579NHLBI NIH HHS R01 HL124074NHLBI NIH HHS R01 HL142579
6 · The paper itself

Abstract

BACKGROUND AND

aimsExtracellular vesicles (EVs) secreted by cardiosphere-derived cells exert immunomodulatory effects through the transmission of small non-coding RNAs.

methodsThe mechanism and role of yREX3, a small Y RNA abundant in EVs in myocardial injury, was investigated.

resultsyREX3 attenuates cardiac ischaemic injury by selective DNA methylation. Synthetic yREX3 encapsulated in lipid nanoparticles triggers broad transcriptomic changes in macrophages, localizes to the nucleus, and mediates epigenetic silencing of protein interacting with C kinase-1 (Pick1) through methylation of upstream CpG sites. Moreover, yREX3 interacts with polypyrimidine tract binding protein 3 (PTBP3) to methylate the Pick1 gene locus in a DNA methyltransferase-dependent manner. Suppression of Pick1 in macrophages potentiates Smad3 signalling and enhances efferocytosis, minimizing heart necrosis in rats with myocardial infarction. Adoptive transfer of Pick1-deficient macrophages recapitulates the cardioprotective effects of yREX3 in vivo.

conclusionsThese findings highlight the role of a small Y RNA mined from EVs with a novel gene-methylating mechanism.

Indexed as

Extracellular VesiclesMacrophagesAnimalsCarrier ProteinsDNA MethylationHumansMaleMyocardial InfarctionNuclear ProteinsRatsRNA, Long NoncodingCarrier ProteinsNuclear ProteinsRNA, Long NoncodingEfferocytosisInflammationMacrophagesMyocardial infarctionPick1Small non-coding RNA

Identifiers

PMID38865332
PMCPMC11297535

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.