ArticleNeuro-degenerative diseases2024
Classification of Mild Cognitive Impairment and Alzheimer's Disease Using Manual Motor Measures.
Article in Neuro-degenerative diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- White matter microstructure and motor function in amnestic mild cognitive impairment and Alzheimer's dementia.Neuroimage. Reports · 2026Article
- Early Detection of Cognitive Impairment Using Time-Frequency Analysis of Fine Motor Accelerometry.Annals of biomedical engineering · 2026Article
- Article
- Large reaching datasets quantify the impact of age, sex/gender, and experience on motor control.Communications psychology · 2026Article
- Perceiving, interpreting and responding to changes in hand function among older adults with mild cognitive impairment: a common-sense model-informed qualitative study.Frontiers in psychiatry · 2026Article
- Average performance and performance variability on a brief functional fine motor test reflect distinct behavioral constructs in aging.Frontiers in aging neuroscience · 2026Article
- Clinical Applications and Measurement Properties of the Digitized Archimedes Spiral Drawing Test: A Scoping Review.Movement disorders clinical practice · 2025Article
- Quantifying Mild Cognitive Impairments in Older Adults Using Multi-modal Wearable Sensor Data in a Kitchen Environment.medRxiv : the preprint server for health sciences · 2025Article
- Differences in Finger Dexterity in Patients With Mild and Moderate Alzheimer's Disease-A Study of Cognitive Function by Disease Severity.Brain and behavior · 2025Article
- Cognitive and motor disturbances in depression: insights from comprehensive behavioral assessments.Frontiers in psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
introductionManual motor problems have been reported in mild cognitive impairment (MCI) and Alzheimer's disease (AD), but the specific aspects that are affected, their neuropathology, and potential value for classification modeling is unknown. The current study examined if multiple measures of motor strength, dexterity, and speed are affected in MCI and AD, related to AD biomarkers, and are able to classify MCI or AD.
methodsFifty-three cognitively normal (CN), 33 amnestic MCI, and 28 AD subjects completed five manual motor measures: grip force, Trail Making Test A, spiral tracing, finger tapping, and a simulated feeding task. Analyses included (1) group differences in manual performance; (2) associations between manual function and AD biomarkers (PET amyloid β, hippocampal volume, and APOE ε4 alleles); and (3) group classification accuracy of manual motor function using machine learning.
resultsAmnestic MCI and AD subjects exhibited slower psychomotor speed and AD subjects had weaker dominant hand grip strength than CN subjects. Performance on these measures was related to amyloid β deposition (both) and hippocampal volume (psychomotor speed only). Support vector classification well-discriminated control and AD subjects (area under the curve of 0.73 and 0.77, respectively) but poorly discriminated MCI from controls or AD.
conclusionGrip strength and spiral tracing appear preserved, while psychomotor speed is affected in amnestic MCI and AD. The association of motor performance with amyloid β deposition and atrophy could indicate that this is due to amyloid deposition in and atrophy of motor brain regions, which generally occurs later in the disease process. The promising discriminatory abilities of manual motor measures for AD emphasize their value alongside other cognitive and motor assessment outcomes in classification and prediction models, as well as potential enrichment of outcome variables in AD clinical trials.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.