ArticleBiomedical optics express2024
Cellular structural and functional imaging of donor and pathological corneas with label-free dual-mode full-field optical coherence tomography.
Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Quantitative dynamic full-field optical coherence tomography for high-resolution intraoperative imaging of head and neck squamous cell carcinoma.Biomedical optics express · 2026Article
- First-order field autocorrelation function analysis-based dynamic OCT for tissue viability assessment.Biomedical optics express · 2026Article
- Circumferential multi-contrast mapping of the aqueous outflow pathway in human eyes facilitated by circular-scan optical coherence tomography angiography.Biomedical optics express · 2026Article
- Dynamic optical coherence tomography algorithm for label-free assessment of swiftness and occupancy of intratissue moving scatterers.Biomedical optics express · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
In this study, a dual-mode full-field optical coherence tomography (FFOCT) was customized for label-free static and dynamic imaging of corneal tissues, including donor grafts and pathological specimens. Static images effectively depict relatively stable structures such as stroma, scar, and nerve fibers, while dynamic images highlight cells with active intracellular metabolism, specifically for corneal epithelial cells. The dual-mode images complementarily demonstrate the 3D microstructural features of the cornea and limbus. Dual-modal imaging reveals morphological and functional changes in corneal epithelial cells without labeling, indicating cellular apoptosis, swelling, deformation, dynamic signal alterations, and distinctive features of inflammatory cells in keratoconus and corneal leukoplakia. These findings propose dual-mode FFOCT as a promising technique for cellular-level cornea and limbus imaging.
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Registered trials
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