Evidence map›Paper›PMID 38869661›Full record

SynthesisNeuropsychology review2025

A Systematic Review and Meta-Analysis of Social Cognition Among People Living with HIV: Implications for Non-Social Cognition and Social Everyday Functioning.

David E Vance, Rebecca Billings, Crystal Chapman Lambert, Pariya L Fazeli, Burel R Goodin, Mirjam-Colette Kempf, Leah H Rubin, Bulent Turan, Jenni Wise, Gerhard Hellemann and 1 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Neuropsychology review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Targeting NAAG metabolism restores cognition and synaptic integrity in EcoHIV-infected mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

David E VanceSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA. devance@uab.edu.ORCID 0000-0002-0498-6263
Rebecca BillingsUAB Libraries, University of Alabama at Birmingham, Birmingham, AL, USA.
Crystal Chapman LambertSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
Pariya L FazeliSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
Burel R GoodinDepartment of Anesthesiology, Washington University Pain Center, Washington University, St. Louis, MO, USA.
Mirjam-Colette KempfSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
Leah H RubinDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Bulent TuranDepartment of Psychology, Koc University, Rumelifeneri Caddesi, Turkey.
Jenni WiseSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.
Gerhard HellemannDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Junghee LeeDepartment of Psychiatry and Behavioral Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Norman J Haughey · 2006 to 2026
$33.2M
Sex differences in the role of multi-omics in HIV-associated carotid artery atherosclerosisU01HL146204 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI David B. Hanna, Anjali Sharma · 2019 to 2026
$33.2M
UAB-MISS MACS/WIHS Combined Cohort StudyU01HL146192 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI James Benjamin Brock, MIRJAM-COLETTE KEMPF · 2019 to 2026
$23.9M
Intersection of Material-Need Insecurities and HIV and Cardiovascular HealthR01HL155226 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRONGILLO, EDWARD A, TURAN, BULENT · 2020 to 2024
$4.0M
Evaluation of Neurobiological Mechanisms Mediating the Effect of Immune Activation on Neurocognitive Impairment and the Role of Psychosocial Factors Among Women Living with HIVR01MH131177 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Andrea Norcini Pala, Pariya Fazeli Wheeler · 2022 to 2026
$3.3M
Determining the role of social reward learning in social anhedonia in first-episode psychosis using motivational interviewing as a probe in a perturbation-based neuroimaging approachR01MH129351 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael F. Green, Junghee Lee · 2023 to 2026
$2.9M
The Impact of Insomnia on Pain, Physical Function, and Inflammation in HIVR01HL147603 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOODIN, BUREL R., SORGE, ROBERT · 2019 to 2022
$2.8M
Disrupted Social Preference in Early Psychosis: A Longitudinal Multimodal Neuroimaging StudyR01MH113856 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, JUNGHEE · 2018 to 2022
$2.7M
An RCT of Speed of Processing Training in Middle-Aged and Older Adults with HIVR01MH106366 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VANCE, DAVID E · 2016 to 2020
$2.6M
UAB Institutional Career Development Program in HIV-Related Heart, Lung, Blood and ResearchK12HL143958 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HEATH, SONYA L · 2018 to 2022
$1.6M
Feasibility of the Mindfulness-Based Stress Reduction Intervention for BlackWomen Living with HIVK23AT010567 · NCCIH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHAPMAN LAMBERT, CRYSTAL LASHONDA · 2019 to 2022
$681k
Executive Function Training to Reduce Cognitive Intra-Individual Variability in Adults with HIVR21AG077957 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VANCE, DAVID E · 2022 to 2023
$408k
Alzheimer's Association ALZ-NAN-22-926241NCCIH NIH HHS K23 AT010567NCCIH NIH HHS K23AT010567NHLBI NIH HHS K12 HL143958NHLBI NIH HHS K12HL143958NHLBI NIH HHS R01 HL147603NHLBI NIH HHS R01HL147603NHLBI NIH HHS R01 HL155226NHLBI NIH HHS R01HL155226NHLBI NIH HHS U01 HL146192NHLBI NIH HHS U01-HL146192NHLBI NIH HHS U01 HL146204NIA NIH HHS R21 AG077957NIA NIH HHS R21AG077957NIDA NIH HHS R03 DA052180NIDA NIH HHS R03DA052180NIMH NIH HHS 1R01MH131177NIMH NIH HHS P30 MH075673NIMH NIH HHS P30MH075673NIMH NIH HHS R01 MH106366NIMH NIH HHS R01MH106366NIMH NIH HHS R01 MH113856NIMH NIH HHS R01MH113856NIMH NIH HHS R01 MH129351NIMH NIH HHS R01MH129351NIMH NIH HHS R01 MH131177
6 · The paper itself

Abstract

Social cognition-the complex mental ability to perceive social stimuli and negotiate the social environment-has emerged as an important cognitive ability needed for social functioning, everyday functioning, and quality of life. Deficits in social cognition have been well documented in those with severe mental illness including schizophrenia and depression, those along the autism spectrum, and those with other brain disorders where such deficits profoundly impact everyday life. Moreover, subtle deficits in social cognition have been observed in other clinical populations, especially those that may have compromised non-social cognition (i.e., fluid intelligence such as memory). Among people living with HIV (PLHIV), 44% experience cognitive impairment; likewise, social cognitive deficits in theory of mind, prosody, empathy, and emotional face recognition/perception are gradually being recognized. This systematic review and meta-analysis aim to summarize the current knowledge of social cognitive ability among PLHIV, identified by 14 studies focused on social cognition among PLHIV, and provides an objective consensus of the findings. In general, the literature suggests that PLHIV may be at-risk of developing subtle social cognitive deficits that may impact their everyday social functioning and quality of life. The causes of such social cognitive deficits remain unclear, but perhaps develop due to (1) HIV-related sequelae that are damaging the same neurological systems in which social cognition and non-social cognition are processed; (2) stress related to coping with HIV disease itself that overwhelms one's social cognitive resources; or (3) may have been present pre-morbidly, possibly contributing to an HIV infection. From this, a theoretical framework is proposed highlighting the relationships between social cognition, non-social cognition, and social everyday functioning.

Indexed as

Cognitive DysfunctionHIV InfectionsSocial CognitionActivities of Daily LivingHumansQuality of LifeTheory of MindEmotional processingHIVSocial cognitionStigmaTheory of mind

Identifiers

PMID38869661
PMCPMC12328480

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.