Evidence map›Paper›PMID 38869664›Full record

ArticleBiochemical genetics2025

Circ_0000758 Facilitates Bladder Cancer Cell Growth, Migration and Angiogenesis Via Severing as miR-1236-3p Sponge.

Qiang Chi, Zhiyong Wang, Hui Xu, Hongyang Li, Dianbin Song

Abstract read
PubMed Publisher
In one paragraph

Article in Biochemical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qiang ChiDepartment of Urology, Affiliated Hospital of Chengde Medical University, No.36, Nanyingzi Street, Chengde, 067000, Hebei, People's Republic of China. chi_qiang.2007@163.com.
Zhiyong WangDepartment of Urology, Affiliated Hospital of Chengde Medical University, No.36, Nanyingzi Street, Chengde, 067000, Hebei, People's Republic of China.
Hui XuDepartment of Urology, Affiliated Hospital of Chengde Medical University, No.36, Nanyingzi Street, Chengde, 067000, Hebei, People's Republic of China.
Hongyang LiDepartment of Urology, Affiliated Hospital of Chengde Medical University, No.36, Nanyingzi Street, Chengde, 067000, Hebei, People's Republic of China.
Dianbin SongDepartment of Urology, Affiliated Hospital of Chengde Medical University, No.36, Nanyingzi Street, Chengde, 067000, Hebei, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA (circRNA) has been reported to regulate the development of bladder cancer (BCa). However, the role of circ_0000758 in BCa progression is unknown. Circ_0000758 and miR-1236-3p expression, as well as ZEB2 mRNA expression were determined by qRT-PCR. BCa cell biological functions were determined by MTT assay, EdU assay, flow cytometry, wound healing assay and tube formation assay. Protein expression was detected by western blot analysis. RNA pull-down assay and dual-luciferase reporter assay were used to confirm RNA interaction. Xenograft mice models were constructed to assess the effect of circ_0000758 on BCa tumor growth. Circ_0000758 had increased expression in BCa tissues and cells. Circ_0000758 silencing could inhibit BCa cell growth, migration, angiogenesis in vitro, and tumor growth in vivo. Circ_0000758 served as a molecular sponge for miR-1236-3p, and miR-1236-3p inhibitor reversed circ_0000758 knockdown-mediated the inhibition effect on BCa cell progression. ZEB2 was targeted by miR-1236-3p, and its overexpression also revoked the suppressive effect of miR-1236-3p on BCa cell growth, migration, and angiogenesis. Besides, circ_0000758 knockdown also restrained BCa tumor growth. Circ_0000758 might promote BCa cell growth, migration, and angiogenesis by regulating the miR-1236-3p/ZEB2 axis.

Indexed as

Cell MovementMicroRNAsNeovascularization, PathologicRNA, CircularUrinary Bladder NeoplasmsAngiogenesisAnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, Inbred BALB CMice, NudeMicroRNAsMIRN1236 microRNA, humanRNA, CircularZEB2 protein, humanZinc Finger E-box Binding Homeobox 2Bladder cancercirc_0000758miR-1236-3pZEB2

Identifiers

PMID38869664

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.