Evidence map›Paper›PMID 38870207›Full record

ArticlePloS one2024

Incidence, characteristics, and risk factors of new liver disorders 3.5 years post COVID-19 pandemic in the Montefiore Health System in Bronx.

Thomas Peng, Katie S Duong, Justin Y Lu, Kristina R Chacko, Sonya Henry, Wei Hou, Kevin P Fiori, Stephen H Wang, Tim Q Duong

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas PengDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Katie S DuongDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Justin Y LuDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Kristina R ChackoDepartment of Medicine, Division of Hepatology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Sonya HenryDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.ORCID 0000-0002-6471-4569
Wei HouDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Kevin P FioriDepartment of Pediatrics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Stephen H WangDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Tim Q DuongDepartment of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.ORCID 0000-0001-6403-2827

Funding

Einstein-Montefiore Clinical and Translational Science Award HubUM1TR004400 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Jessica Kahn, Mimi Y Kim · 2023 to 2026
$17.3M
NCATS NIH HHS UM1 TR004400
6 · The paper itself

Abstract

purposeTo determine the incidence of newly diagnosed liver disorders (LD) up to 3.5-year post-acute COVID-19, and risk factors associated with new LD.

methodsWe analyzed 54,699 COVID-19 patients and 1,409,547 non-COVID-19 controls from March-11-2020 to Jan-03-2023. New liver disorders included abnormal liver function tests, advanced liver failure, alcohol and non-alcohol related liver disorders, and cirrhosis. Comparisons were made with ambulatory non-COVID-19 patients and patients hospitalized for other lower respiratory tract infections (LRTI). Demographics, comorbidities, laboratory data, incomes, insurance status, and unmet social needs were tabulated. The primary outcome was new LD at least two weeks following COVID-19 positive test.

resultsIncidence of new LD was not significantly different between COVID-19 and non-COVID-19 cohorts (incidence:1.99% vs 1.90% p>0.05, OR = 1.04[95%CI: 0.92,1.17], p = 0.53). COVID-19 patients with new LD were older, more likely to be Hispanic and had higher prevalence of diabetes, hypertension, chronic kidney disease, and obesity compared to patients without new LD. Hospitalized COVID-19 patients had no elevated risk of LD compared to hospitalized LRTI patients (2.90% vs 2.07%, p>0.05, OR = 1.29[0.98,1.69], p = 0.06). Among COVID-19 patients, those who developed LD had fewer patients with higher incomes (14.18% vs 18.35%, p<0.05) and more with lower incomes (21.72% vs 17.23%, p<0.01), more Medicare and less Medicaid insurance, and more patients with >3 unmet social needs (6.49% vs 2.98%, p<0.001) and fewer with no unmet social needs (76.19% vs 80.42%, p<0.001).

conclusionsOlder age, Hispanic ethnicity, and obesity, but not COVID-19 status, posed increased risk for developing new LD. Lower socioeconomic status was associated with higher incidence of new LD.

Indexed as

COVID-19Liver DiseasesAdultAgedComorbidityFemaleHumansIncidenceMaleMiddle AgedNew York CityPandemicsRisk FactorsSARS-CoV-2

Identifiers

PMID38870207
PMCPMC11175509

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.