Evidence map›Paper›PMID 38872193›Full record

Trial reportAdvances in rheumatology (London, England)2024

Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial-the DIETA trial.

Daniele Scherer, Beatriz Figueiredo Leite, Melissa Aparecida Morimoto, Thauana Luiza Oliveira, Barbara N Carvalho Klemz, Rosana A M Soares Freitas, Caroline Pappiani, Nágila R Teixeira Damasceno, Marcelo de Medeiros Pinheiro

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Advances in rheumatology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03142503 (Effectiveness of a Dietary Intervention Program on Disease Activity, Metabolism and Oxidative Stress in Patients With Psoriatic Arthritis and Psoriasis Activity), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03142503 nacompletednot on this map

Effectiveness of a Dietary Intervention Program on Disease Activity, Metabolism and Oxidative Stress in Patients With Psoriatic Arthritis and Psoriasis Activity: A Clinical, Randomized, Placebo-controlled Trial

TypeinterventionalSponsorFederal University of São PauloRan2013 to 2015Enrolled194ConditionsArthritis, Psoriatic, Metabolic SyndromeArmsDiet + supplementation, Diet + placebo, Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniele SchererRheumatology Division, Paulista School of Medicine, Federal University of São Paulo, UNIFESP/EPM), Borges Lagoa Street, 913, room 53, Vila Clementino, São Paulo/SP, 04038-034, Brazil.
Beatriz Figueiredo LeiteRheumatology Division, Paulista School of Medicine, Federal University of São Paulo, UNIFESP/EPM), Borges Lagoa Street, 913, room 53, Vila Clementino, São Paulo/SP, 04038-034, Brazil.
Melissa Aparecida MorimotoRheumatology Division, Paulista School of Medicine, Federal University of São Paulo, UNIFESP/EPM), Borges Lagoa Street, 913, room 53, Vila Clementino, São Paulo/SP, 04038-034, Brazil.
Thauana Luiza OliveiraRheumatology Division, Paulista School of Medicine, Federal University of São Paulo, UNIFESP/EPM), Borges Lagoa Street, 913, room 53, Vila Clementino, São Paulo/SP, 04038-034, Brazil.
Barbara N Carvalho KlemzRheumatology Division, Paulista School of Medicine, Federal University of São Paulo, UNIFESP/EPM), Borges Lagoa Street, 913, room 53, Vila Clementino, São Paulo/SP, 04038-034, Brazil.
Rosana A M Soares FreitasNutrition Department, School of Public Health, University of São Paulo, São Paulo, Brazil.
Caroline PappianiNutrition Department, School of Public Health, University of São Paulo, São Paulo, Brazil.
Nágila R Teixeira DamascenoNutrition Department, School of Public Health, University of São Paulo, São Paulo, Brazil.
Marcelo de Medeiros PinheiroRheumatology Division, Paulista School of Medicine, Federal University of São Paulo, UNIFESP/EPM), Borges Lagoa Street, 913, room 53, Vila Clementino, São Paulo/SP, 04038-034, Brazil. mpinheiro@uol.com.br.ORCID 0000-0002-7901-3124

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São Paulo 2012/18701-2Fundação de Amparo à Pesquisa do Estado de São Paulo 2012/18789-7Sociedade Brasileira de Reumatologia Sociedade Brasileira de Reumatologia
6 · The paper itself

Abstract

introductionPatients with psoriatic arthritis have some lipid metabolism changes and higher risk of metabolic syndrome (MetS) and cardiovascular diseases, regardless of traditional risk factors, suggesting that chronic inflammation itself plays a central role concerning the atherosclerosis. However, there is a lack of information regarding atherogenic pattern and lipoprotein subfractions burden in these individuals.

aimTo evaluate the HDL and LDL-cholesterol plasmatic levels and their subfractions after a nutritional intervention in patients with psoriatic arthritis (PsA).

methodsThis was a randomized, placebo-controlled clinical trial of a 12-week nutritional intervention. PsA patients were randomly assigned to 1-Placebo: 1 g of soybean oil daily, no dietetic intervention; 2-Diet + Supplementation: an individualized diet, supplemented with 604 mg of omega-3 fatty acids, three times a day; and 3-Diet + Placebo: individualized diet + 1 g of soybean oil. The LDL subfractions were classified as non-atherogenic (NAth), atherogenic (Ath) or highly atherogenic (HAth), whereas the HDL subfractions were classified as small, medium, or large particles, according to the current recommendation based on lipoproteins electrophoresis.

resultsA total of 91 patients were included in the study. About 62% of patients (n = 56) had an Ath or HAth profile and the main risk factors associated were male gender, longer skin disease duration and higher BMI. Thirty-two patients (35%) had a high-risk lipoprotein profile despite having LDL plasmatic levels below 100 mg/dL. The 12-week nutritional intervention did not alter the LDL subfractions. However, there were significant improvement of HDL subfractions.

conclusionRecognizing the pro-atherogenic subfractions LDL pattern could be a relevant strategy for identifying PsA patients with higher cardiovascular risk, regardless total LDL plasmatic levels and disease activity. In addition, a short-term nutritional intervention based on supervised and individualized diet added to omega-3 fatty acids changed positively the HDL CLINICALTRIALS: gov identifier: NCT03142503 ( http://www. CLINICALTRIALS: gov/ ).

Indexed as

Arthritis, PsoriaticCholesterol, HDLCholesterol, LDLAdultAtherosclerosisDietary SupplementsFatty Acids, Omega-3FemaleHumansMaleMiddle AgedSoybean OilCholesterol, HDLCholesterol, LDLFatty Acids, Omega-3Soybean OilElectrophoresisHDL cholesterolLDL cholesterolLipoproteins subfractionsNutritional interventionPsoriatic arthritis

Identifiers

PMID38872193
PMCPMC13488697

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.