Evidence map›Paper›PMID 38872853›Full record

ArticleExtracellular vesicle2024

The EV antibody database: An interactive database of curated antibodies for extracellular vesicle and nanoparticle research.

Amber Morey, Martin Ng, Michail Spanos, Piyan Zhang, Tuoye Xu, Willi Cheung, Emeli Chatterjee, Priyanka Gokulnath, Natacha Carnel-Amar, Ana Luisa Soares Chiaretti and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Extracellular vesicle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Amber MoreyUniversity of California San Diego, Department of Obstetrics, Gynecology, and Reproductive Medicine, La Jolla, CA 92093, USA.
Martin NgDepartment of Veterans Affairs, Surgical Service (112G), San Francisco VA Medical Center, San Francisco, CA 94121, USA.
Michail SpanosCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Piyan ZhangBeth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA, 02215, USA.
Tuoye XuBeth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA, 02215, USA.
Willi CheungUniversity of California San Diego, Department of Obstetrics, Gynecology, and Reproductive Medicine, La Jolla, CA 92093, USA.
Emeli ChatterjeeCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Priyanka GokulnathCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Natacha Carnel-AmarCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ana Luisa Soares ChiarettiCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Collin NelsonMeso Scale Diagnostics, Rockville, MD, 20850, USA.
Jubin GeorgeTranslational Nanobiology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA.
Michelle LuoTranslational Nanobiology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA.
Abhik ChakrabortyUniversity of California San Diego, Department of Obstetrics, Gynecology, and Reproductive Medicine, La Jolla, CA 92093, USA.
Luiza PerucciUniversity of California San Diego, Department of Obstetrics, Gynecology, and Reproductive Medicine, La Jolla, CA 92093, USA.
Jennifer C JonesTranslational Nanobiology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA.
Peter De HoffUniversity of California San Diego, Department of Obstetrics, Gynecology, and Reproductive Medicine, La Jolla, CA 92093, USA.
Jeffrey L FranklinDepartment of Medicine, Vanderbilt University Medical Center, Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
Robert L RaffaiDepartment of Veterans Affairs, Surgical Service (112G), San Francisco VA Medical Center, San Francisco, CA 94121, USA.
Saumya DasCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
David A RoutenbergMeso Scale Diagnostics, Rockville, MD, 20850, USA.
John P NolanScintillon Institute, San Diego, CA, 92121, USA.
Al CharestBeth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA, 02215, USA.
Louise C LaurentUniversity of California San Diego, Department of Obstetrics, Gynecology, and Reproductive Medicine, La Jolla, CA 92093, USA.
Roger P AlexanderExtracellular RNA Communication Consortium, Phoenix, AZ 85254, USA.

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Development and use of nanoFACS for analysis and sorting of nanoparticlesZIABC011502 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2013 to 2025
$8.6M
Novel Combinations of Radiation and ImmunotherapyZIABC011503 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2013 to 2025
$5.3M
Scientific Outreach ComponentU54DA049098 · NIDA · BAYLOR COLLEGE OF MEDICINE · PI ROTH, MATT · 2019 to 2022
$5.0M
TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
Molecular dissection and imaging of extracellular vesicles to define their origin and targetsUH3TR002878 · NCATS · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA, TALISMAN, TIJANA · 2021 to 2022
$2.2M
Uncovering exRNA and protein determinants of secreted vesicle heterogeneity by flow cytometric purification of vesicle subsets from cells and plasmaUH3CA241685 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHAREST, ALAIN, COFFEY, ROBERT J. · 2021 to 2022
$2.1M
Quantitative Analysis of Cancer-associated EVsR44CA272098 · NCI · CELLARCUS BIOSCIENCES INC · PI NOLAN, JOHN P · 2023 to 2024
$2.0M
Development and application of a scalable workflow for immunomagnetic separation of exRNA carrier subclasses and molecular analysis of their cargoUH3CA241687 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAURENT, LOUISE CHANG · 2021 to 2022
$2.0M
Enabling isolation and characterization of single extracellular vesicles and their molecular contents using multi-marker surface signaturesUH3TR002886 · NCATS · MESO SCALE DIAGNOSTICS, LLC · PI ROUTENBERG, DAVID AARON · 2021 to 2022
$2.0M
Assays and kits for MSC-derived extracellular vesiclesR44GM136165 · NIGMS · CELLARCUS BIOSCIENCES INC · PI NOLAN, JOHN P · 2020 to 2021
$1.6M
P.R.I.S.M: Purification of exRNA by Immuno-capture and Sorting using MicrofluidicUH3CA241703 · NCI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MATEESCU, BOGDAN, RAFFAI, ROBERT · 2021 to 2022
$1.4M
BLRD VA I01 BX003928BLRD VA IK6 BX005692NCATS NIH HHS UG3 TR002878NCATS NIH HHS UG3 TR002886NCATS NIH HHS UH3 TR002878NCATS NIH HHS UH3 TR002886NCI NIH HHS R44 CA272098NCI NIH HHS UG3 CA241685NCI NIH HHS UG3 CA241687NCI NIH HHS UG3 CA241703NCI NIH HHS UH3 CA241685NCI NIH HHS UH3 CA241687NCI NIH HHS UH3 CA241703NICHD NIH HHS T32 HD007203NIDA NIH HHS U54 DA049098NIDDK NIH HHS P30 DK058404NIGMS NIH HHS R44 GM136165
6 · The paper itself

Abstract

Antibodies are critical tools for research into extracellular vesicles (EVs) and other extracellular nanoparticles (ENPs), where they can be used for their identification, characterization, and isolation. However, the lack of a centralized antibody platform where researchers can share validation results thus minimizing wasted personnel time and reagents, has been a significant obstacle. Moreover, because the performance of antibodies varies among assay types and conditions, detailed information on assay variables and protocols is also of value. To facilitate sharing of results on antibodies that are relevant to EV/ENP research, the EV Antibody Database has been developed by the investigators of the Extracellular RNA Communication Consortium (ERCC). Hosted by the ExRNA Portal (https://exrna.org/resources/evabdb/), this interactive database aggregates and shares results from antibodies that have been tested by research groups in the EV/ENP field. Currently, the EV Antibody Database includes modules for antibodies tested for western Blot, EV Flow Cytometry, and EV Sandwich Assays, and holds 110 records contributed by 6 laboratories from the ERCC. Detailed information on antibody sources, assay conditions, and results is provided, including negative results. We encourage ongoing expert input and community feedback to enhance the database's utility, making it a valuable resource for comprehensive validation data on antibodies and protocols in EV biology.

Indexed as

AntibodiesAntibody databaseExosomesExtracellular vesiclesNanoparticles

Identifiers

PMID38872853
PMCPMC11175471

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.