ArticleExperimental and therapeutic medicine2024
Chest non‑contrasted computed tomography in detecting acute pulmonary thromboembolism: A single‑center retrospective study.
Article in Experimental and therapeutic medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Artificial intelligence in computed tomography imaging for pulmonary embolism: a narrative review from computed tomography pulmonary angiography to non-contrast computed tomography.Quantitative imaging in medicine and surgery · 2026Review
- Reply to Finsterer: Why HAPE Was the Most Likely Diagnosis in This Case.Internal medicine (Tokyo, Japan) · 2026Article
- Quantitative perfusion imaging from non-contrast micro-ct for pulmonary embolism evaluation in preclinical models.Physics in medicine and biology · 2026Article
- Transferring thrombus labels from CTPA to non-contrast CT via accurate pulmonary vessel registration: a critical step toward AI-based pulmonary embolism detection.Quantitative imaging in medicine and surgery · 2026Article
- Unenhanced CT quantitative vascular morphometry for detecting central pulmonary embolism: a multicenter study.Quantitative imaging in medicine and surgery · 2026Article
- The diagnostic efficacy of unenhanced CT for detecting acute central pulmonary embolism.BMC cardiovascular disorders · 2025Article
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Abstract
The object of the study was to evaluate comprehensively the value of chest non-contrasted CT (NC-CT) in detecting acute pulmonary thromboembolism (APE). All patients were categorized into two groups: i) With APE; and ii) without APE based on clinical diagnosis. Using the clot distribution on computed tomography pulmonary angiography (CTPA), APE was divided into central and peripheral APE. Imaging features including hyperdense lumen sign and peripheral wedge-shaped opacity on chest NC-CT were evaluated. The attenuation value of peripheral wedge-shaped opacity on NC-CT was compared between patients with and without APE. Among the 273 patients, there were 110 patients with APE, 49 patients with central APE and 61 patients with peripheral APE and 163 patients without APE. The hyperdense lumen sign had a sensitivity of 30.0% and a specificity of 97.6% in detecting APE. The sensitivity and specificity of hyperdense lumen sign in detecting central APE were 57.1 and 97.6%, respectively, while the relevant percentages in detecting peripheral APE were 8.2 and 97.6%, respectively. The mean attenuation value of peripheral wedge-shaped opacity in patients with APE was significantly lower than that in patients without APE (P<0.001). Regarding the age-adjusted D-dimer, there was a decrease of eight D-dimer positive cases for patients >50 years old without APE, confirmed by CTPA. In conclusion, chest NC-CT cannot be used as an alternative modality for CTPA in diagnosing APE, however, the hyperdense lumen sign had high specificity in the diagnosis of central APE. Patients with this symptom and increased D-dimer may not require further CTPA. The lower attenuation value of peripheral wedge-shaped opacity on NC-CT suggested APE, and CTPA confirmation was required. The age-adjusted D-dimer had higher specificity in excluding APE.
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