Evidence map›Paper›PMID 38874317›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Long-term impact of type 2 diabetes onset on dementia incidence rate among New Zealanders with impaired glucose tolerance: A tapered-matched landmark analysis over 25 years.

Dahai Yu, Zheng Wang, Uchechukwu Levi Osuagwu, Karen Pickering, John Baker, Richard Cutfield, Yamei Cai, Brandon J Orr-Walker, Gerhard Sundborn, Bingjie Qu and 2 more

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dahai YuDepartment of Nephrology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.ORCID 0000-0002-8449-7725
Zheng WangDepartment of Nephrology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Uchechukwu Levi OsuagwuTranslational Health Research Institute (THRI), Western Sydney University, Sydney, New South Wales, Australia.
Karen PickeringDiabetes Foundation Aotearoa, Otara, Auckland, New Zealand.
John BakerDiabetes Foundation Aotearoa, Otara, Auckland, New Zealand.
Richard CutfieldDiabetes Foundation Aotearoa, Otara, Auckland, New Zealand.
Yamei CaiDepartment of Nephrology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Brandon J Orr-WalkerDiabetes Foundation Aotearoa, Otara, Auckland, New Zealand.
Gerhard SundbornSection of Pacific Health, the University of Auckland, Auckland, New Zealand.
Bingjie QuDepartment of Nephrology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Zhanzheng ZhaoDepartment of Nephrology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
David SimmonsDepartment of Nephrology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.ORCID 0000-0003-0560-0761

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe aimed to investigate the association between the onset of type 2 diabetes (T2D) and dementia incidence rates (IR) in the population with impaired glucose tolerance (IGT) identified in primary care in New Zealand (NZ) over 25 years.

methodsTapered matching and landmark analysis (accounting for immortal bias) were used to control for potential effects of known confounders. The association between T2D onset and 5- and 10-year IR of dementia was estimated by weighted Cox models.

resultsThe onset of T2D was significantly associated with the 10-year IR of dementia, especially in the socioeconomically deprived, those of non-NZ European ethnicity, those currently smoking, and patients with higher metabolic measures. DISCUSSION: Our findings suggest that the onset of T2D is a significant risk factor for dementia in individuals with IGT. Dementia screening and structured diabetes prevention are vital in the population with IGT, particularly those from deprived or ethnic minority backgrounds. HIGHLIGHTS: Increased dementia incidence rate links with T2D onset in people with IGT. Significant incidence varied by ethnicity, socioeconomic status, and health factors. Results emphasize the diabetes manage and socioeconomic factors on dementia risk. Secondary analysis highlights the key role of vascular health in dementia prevention.

Indexed as

DementiaDiabetes Mellitus, Type 2Glucose IntoleranceAgedAged, 80 and overAustralasian PeopleFemaleHumansIncidenceMaleMiddle AgedNew ZealandRisk Factorsdementiaimpaired glucose tolerancelandmark analysistapered matchingtype 2 diabetes

Identifiers

PMID38874317
PMCPMC11247710

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.