Evidence map›Paper›PMID 38874802›Full record

ArticleMolecular biology reports2024

Effects of mesenchymal stem cells versus curcumin on sonic hedgehog signaling in experimental model of Hepatocellular Carcinoma.

Marwa Sayed Abdel-Tawab, Hanan Fouad, Ahmed Yahia Sedeak, Noha A Doudar, Enas Ezzat Rateb, Eman Faruk, Hoda Ramadan Reyad

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marwa Sayed Abdel-TawabMedical Biochemistry Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. Drmarwasayed2016@gmail.com.
Hanan FouadMedical Biochemistry Department, Faculty of Medicine, Cairo University, POB 12613, Cairo, Egypt.
Ahmed Yahia SedeakAnatomy and Embryology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Noha A DoudarClinical and Chemical Pathology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Enas Ezzat RatebPhysiology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Eman FarukDepartment of Anatomy, Faculty of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia.
Hoda Ramadan ReyadMedical Biochemistry Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSonic Hedgehog (SHH) is a fundamental signaling pathway that controls tissue reconstruction, stem cell biology, and differentiation and has a role in gut tissue homeostasis and development. Dysregulation of SHH leads to the development of HCC. METHODS, AND

resultsThe present study was conducted to compare the effects of mesenchymal stem cells (MSCs) and curcumin on SHH molecular targets in an experimental model of HCC in rats. One hundred rats were divided equally into the following groups: control group, HCC group, HCC group received MSCs, HCC group received curcumin, and HCC group received MSCs and curcumin. Histopathological examinations were performed, and gene expression of SHH signaling target genes (SHH, PTCH1, SMOH, and GLI1) was assessed by real-time PCR in rat liver tissue. Results showed that SHH target genes were significantly upregulated in HCC-untreated rat groups and in MSC-treated groups, with no significant difference between them. Administration of curcumin with or without combined administration of MSCs led to a significant down-regulation of SHH target genes, with no significant differences between both groups. As regards the histopathological examination of liver tissues, both curcumin and MSCs, either through separate use or their combined use, led to a significant restoration of normal liver pathology.

conclusionsIn conclusion, SHH signaling is upregulated in the HCC experimental model. MSCs do not inhibit the upregulated SHH target genes in HCC. Curcumin use with or without MSCs administration led to a significant down-regulation of SHH signaling in HCC and a significant restoration of normal liver pathology.

Indexed as

Carcinoma, HepatocellularCurcuminHedgehog ProteinsLiver NeoplasmsMesenchymal Stem CellsSignal TransductionAnimalsDisease Models, AnimalGene Expression Regulation, NeoplasticLiverMaleMesenchymal Stem Cell TransplantationPatched-1 ReceptorRatsZinc Finger Protein GLI1CurcuminGli1 protein, ratHedgehog ProteinsPatched-1 ReceptorShh protein, ratZinc Finger Protein GLI1And GLI1CurcuminHCCMSCsPTCH1SHHSMOHSonic hedgehog

Identifiers

PMID38874802

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.